As one of the crucial targets epigenetics, histone lysine-specific demethylase 1 (LSD1) is significant in occurrence and development various tumors. Although several irreversible covalent LSD1 inhibitors have entered clinical trials, large size polarity FAD-binding pocket undesired toxicity focused interest on developing reversible inhibitors. In this study, targeting substrate-binding LSD1, st...

Copper active sites play a major role in biological and abiological dioxygen activation. Oxygen intermediates have been studied in detail for the proteins and enzymes involved in reversible O(2) binding (hemocyanin), activation (tyrosinase), and four-electron reduction to water (multicopper oxidases). These oxygen intermediates exhibit unique spectroscopic features indicative of new geometric a...

High affinity and specificity are considered essential for affinity reagents and molecularly-targeted therapeutics, such as monoclonal antibodies. However, life's own molecular and cellular machinery consists of lower affinity, highly multivalent interactions that are metastable, but easily reversible or displaceable. With this inspiration, we have developed a DNA-based reagent platform that us...

Peroxo formation is the crucial step in oxygen redox. In their Research Article on page 10056, Bjoern Schwarz, Xiao Cheng Zeng, Jun Li, and co-workers report reversible peroxo species formed confined high-capacity silicate cathodes. The picture shows dominating binding mode of species, which forms delithiation amid high-voltage charging reverses lithium re-intercalation during discharging. tran...

The calcium ion response of a quartz nanopipette was enhanced by immobilization of calmodulin to the nanopore surface. Binding to the analyte is rapidly reversible in neutral buffer and requires no change in media or conditions to regenerate the receptor. The signal remained reproducible over numerous measurements. The modified nanopipette was used to measure binding affinity to calcium ions, w...