The C57BLKS/J db/db mouse develops hyperglycemia and has delayed gastric emptying that is improved with tegaserod, a partial 5-HT4 agonist. Our aims here were to determine regional gastric contractility alterations in C57BLKS/J db/db mice and to determine the effects of serotonin and tegaserod. The contractile effects of bethanechol, serotonin, and tegaserod in fundic, antral, and pyloric circu...

BACKGROUND Asthmatics are known to have esophageal hypomotility. Vagal hypofunction and prolonged intra-esophageal acidification cause esophageal hypomotility. The contribution of gastroesophageal reflux (GER) and vagal function to esophageal motility in asthmatics is unclear. We studied the relationship between esophageal motility, GER and vagal function in a cohort of adult asthmatics. METH...

Cholelithiasis is one of the major health problems around world. The prevalence cholelithiasis varies by country. ethnicity people and geographical location a country has huge role in gallstone disease. etiology gallstones not well understood. most important predisposition factor formation supersaturation cholesterol, hypomotility gallbladder, excess bilirubin. Gallstones risk factors are multi...

A case of pediatric progressive systemic sclerosis is reported and a literature review concerning medical and dental aspects of this condition is provided. Systemic features include sclerodactyly, Raynaud's phenomenon, telangiectasia, calcinosis, myositis, arthritis, tenosynovitis, renal failure, esophageal hypomotility, pulmonary fibrosis and heart failure. Oral manifestations include reduced ...

Neuropeptide Y (NPY) is a strong stimulant of feed intake in sheep as well as in rodents. The information available indicates that it functions in vivo in the modulation of feeding within the central nervous system, more specifically, within the hypothalamus, and probably within the paraventricular nucleus. Injected NPY can override a variety of satiating factors, including those arising from n...

Megacolon is a relatively rare condition appearing in childhood and characterised by obstinate constipation, dilatation of the colon and hypomotility of its wall. It was Yon Ammon who first described megacolon in 1842, fortyfive years before Hirschsprung, though the disease carries the name of the latter. Since then many {etiological factors have been considered, ranging from malnutrition to ne...