The transmembrane voltage induced due to applied electric field superimposes to the resting transmembrane voltage of the cell. On the part of the cell membrane, where the transmembrane voltage exceeds the threshold transmembrane voltage, changes in the membrane occur, leading to increase in membrane permeability known as electropermeabilization. This part of the cell membrane represents the per...

Ruff, Robert L. Effects of temperature on slow and fast inactivation of rat skeletal muscle Na1 channels. Am. J. Physiol. 277 (Cell Physiol. 46): C937–C947, 1999.—Patchclamp studies of mammalian skeletal muscle Na1 channels are commonly done at subphysiological temperatures, usually room temperature. However, at subphysiological temperatures, most Na1 channels are inactivated at the cell restin...

BACKGROUND Inflammation is an important underlying mechanism in the pathogenesis of atherosclerosis, and an elevated resting heart rate underlies the process of atherosclerotic plaque formation. We hypothesized an association between resting heart rate and subclinical inflammation. METHODS Resting heart rate was recorded at baseline in the KoGES-ARIRANG (Korean Genome and Epidemiology Study o...

Resting B lymphocytes have been credited with inducing T cell tolerance to Ig-derived and monovalent self-Ags that are internalized via the B cell receptor (BCR). These conclusions are predicated upon the assumptions that resting B cells display BCR-associated peptides in class II MHC and that the cells remain quiescent during the course of experimental manipulation. To determine whether restin...

Chronic hypoxia (CH) results in reduced sensitivity to vasoconstrictors in conscious rats that persists upon restoration of normoxia. We hypothesized that this effect is due to endothelium-dependent hyperpolarization of vascular smooth muscle (VSM) cells after CH. VSM cell resting membrane potential was determined for superior mesenteric artery strips isolated from CH rats (PB = 380 Torr for 48...

Chronic hypoxia (CH) results in reduced sensitivity to vasoconstrictors in conscious rats that persists upon restoration of normoxia. We hypothesized that this effect is due to endothelium-dependent hyperpolarization of vascular smooth muscle (VSM) cells following CH. VSM cell resting membrane potential was determined for superior mesenteric artery strips isolated from CH rats (PB = 380 torr; 4...

In order to develop the methods of thermodynamic analysis for the living cell, two models of protoplasm microstructure of the living cell in resting state were suggested. Both models are based on the assumption that the Ling's cell as a statistical mechanics system is non-ergodic. In the first,Van der Waals model, the protein-protein interactions, which form the physical basis for the cell func...