fragility curves represent the probabilities that structural damages, under various levels of seismic excitation, will exceed the specified damage states by means of earthquake intensity damage relations. conceptual aspects related to seismic vulnerability, damage and risk evaluation are discussed first, together with a short review of the most widely used possibilities for the seismic evaluati...

At present, regulatory assessment of systemic toxicity is almost solely carried out using animal models. The European Commission's REACH legislation stimulates the use of animal-free approaches to obtain information on the toxicity of chemicals. In vitro toxicity tests provide in vitro concentration-response curves for specific target cells, whereas in vivo dose-response curves are regularly us...

The Principal Response Curve model is of use to analyze multivariate data resulting from experiments involving repeated sampling in time. The time-dependent treatment effects are represented by Principal Response Curves (PRCs), which are functional in nature. The sample PRCs can be estimated using a raw approach, or the newly proposed smooth approach. The generalizability of the sample PRCs can...

This letter studies frequency-locked rotations in a phaselocked loop (PLL) circuit as FM demodulator. A rotation represents a desynchronized steady state in the PLL circuit and is regarded as another type of self-excited oscillations with natural rotation frequencies. The rotation frequency can be locked at driving frequencies of modulation signals. This letter shows response curves for harmoni...

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1 reveals the synchronization properties of mouse globus 2 pallidus neurons 3 4 Abbreviated title: A direct spectral estimate of the iPRC 5 6 Joshua A. Goldberg1,2, Jeremy F. Atherton1 and D. James Surmeier1 7 8 1Department of Physiology, Feinberg School of Medicine, Northwestern University, 9 Chicago, Illinois, 60611 10 2Department of Medical Neurobiology, Institute of Medical Research Israel-...

A possible experimental design for combination experiments is to compare the dose-response curve of a single agent with the corresponding curve of the same agent using either a fixed amount of a second one or a fixed dose ratio. No interaction is then often defined by a parallel shift of these curves. We have performed a systematic study for various types of dose-response relations both for the...

Phase response curve (PRC) of an oscillatory neuron describes the response of the neuron to external perturbation. The PRC is useful to predict synchronized dynamics of neurons; hence, its measurement from experimental data attracts increasing interest in neural science. This paper introduces a Bayesian method for estimating PRCs from data, which allows for the correlation of errors in explanat...