Sin Nombre virus (SNV) and Andes virus (ANDV) cause most of the hantavirus pulmonary syndrome (HPS) cases in North and South America, respectively. The chances of a patient surviving HPS are only two in three. Previously, we demonstrated that SNV and ANDV DNA vaccines encoding the virus envelope glycoproteins elicit high-titer neutralizing antibodies in laboratory animals, and (for ANDV) in non...

The aim of this study is to investigate the novel application of a ‎handheld near infra-red spectrophotometer coupled with classification methodologies as a screening approach in detection of adulterated lime juices. For this purpose, a miniaturized near infra-red spectrophotometer (Tellspec®) in the spectral range of 900–1700 nm was used. Three diffuse reflectance spectra of 31 pure...

Near-infrared (NIR) spectra of pharmaceutical tablets get affected by light scattering phenomena, which mask the underlying peaks related to chemical components. Often best performing scatter correction technique is selected from a pool pre-selected techniques. However, data corrected with different techniques may carry complementary information, hence, use single sub-optimal. In this study, ai...

Quality control of Chinese herbal medicines requires reliable and rapid detection techniques, Many scholars have used NIR spectroscopy for research in medicine industry. The aim this study was to evaluate the feasibility combining machine learning predict adulteration content Astragalus polysaccharides. astragalus polysaccharide rice flour were mixed form adulterant with different concentration...

Specific therapy is not available for the treatment of hantavirus cardiopulmonary syndrome caused by Sin Nombre virus (SNV). The entry of pathogenic hantaviruses into susceptible human cells is dependent upon expression of the alpha(v)beta(3) integrin, and transfection of human beta(3) integrin is sufficient to confer infectibility onto CHO (Chinese hamster ovary) cells. Furthermore, pretreatme...

25 Sin Nombre virus (SNV) is a rodent-borne hantavirus that causes hantavirus pulmonary 26 syndrome (HPS) predominantly in North America. SNV infection of immunocompetent 27 hamsters results in an asymptomatic infection; the only lethal disease model for a 28 pathogenic hantavirus is Andes virus (ANDV) infection of Syrian hamsters. Efforts to 29 create a lethal SNV disease model in hamsters by ...

Iron is an essential element used as supplement in different dosage-forms. Different time and expenditure-consuming methods introduced for detection and determination of elemental ions such as atomic absorption. In this research, two different and routine methods containing ATR-IR and atomic absorption were applied to define the amount of iron in 198 samples containing different concentrations ...

Previous data indicate that immune mechanisms may be involved in developing capillary leakage during Sin Nombre virus (SNV) infection. Therefore, we investigated production of tumor necrosis factor alpha (TNF-alpha) by human alveolar macrophages and human umbilical vein endothelial cells (HUVEC) after infection with SNV. In addition, we examined the effect of TNF-alpha on HUVEC monolayer leakag...

Sin Nombre virus (SNV), Andes virus (ANDV), and Laguna Negra virus (LANV) have been known as the dominant causative agents of hantavirus pulmonary syndrome (HPS). ANDV and LANV, with different patterns of pathogenicity, exist in a sympatric relationship. Moreover, there is documented evidence of person-to-person transmission of ANDV. Therefore, it is important in clinical medicine and epidemiol...

Animals infected with pathogens often differ in behaviour from their uninfected counterparts, and these differences may be key to understanding zoonotic pathogen transmission. To explore behavioural heterogeneity and its role in pathogen transmission, we studied deer mice, Peromyscus maniculatus, under field conditions. Deer mice are the natural host of Sin Nombre virus (SNV), a zoonotic pathog...