infectious diseases are one of the most common causes of morbidity and mortality and the spread of resistant microorganisms is playing a significant role in this regard. the purpose of this study was to assess the trend in antimicrobial resistance of gram-positive bacteria at the main referral teaching hospital in tehran during a 4-year period. all patients' biological isolates such as blood, u...

antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (cq) and amodiaquine (aq), have been used to prevent and treat malaria for many years. the importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. in recent years, with the spread of parasite resistance to cq and cross-resist...

background: acinetobacter baumannii is an opportunistic and gram-negative coccobacillus. this opportunistic pathogen infectivity, especially in the intensive care units of hospitals is extensive worldwide. due to the incremental pattern of antibiotic resistance, this study was carried out to track the class i, ii and iii integrons in acinetobacter baumannii isolated from hospitalized cases in m...

objective(s):helicobacter pylori (h. pylori) is a pathogenic bacterium that colonizes the stomachs of approximately 50% of the world’s population. resistance of h. pylori to antibiotics is considered as the main reason for the failure to eradicate this bacterium. the aim of this study was to determine the rate of resistant h. pylori strains to various antimicrobial agents in different areas of ...

nowadays the most difficult problem in treatment of bacterial infections is the appearance of resistant bacteria to the antimicrobial agents so that the attention is being drawn to other potential targets. in view of the positive findings of phage therapy, many advantages have been mentioned which utilizes phage therapy over chemotherapy and it seems to be a promising agent to replace the antib...

background and objectives: cholera is an endemic diarrheal disease in iran, caused by vibrio cholerae . the epidemiology, transmission route, environmental determinants and antimicrobial resistant pattern of cholera have been changed during recent years. in this study the epidemiology and antimicrobial resistance of cholera in iran during 2013 outbreak was investigated. materials and methods: a...

background and objectives: the prevalence of vibrio parahaemolyticus has been reported from ponnani earlier, however incidence of multidrug resistant strains have been encountered recently in clinical laboratories. the source for such strains and their presence in this major fish landing centre has been investigated. materials and methods: antibiotic sensitivity tests on isolates of v. parahaem...

conclusions metabolic abnormalities in bscl may prove fatal necessitating optimal therapeutic and preventive measures. patients are advised low fat diet with enhanced physical activities. other treatments include metformin, n-3 polyunsaturated fatty acids and leptin replacement for correction of metabolic complications. we report this case of bscl in view of its rarity. case presentation an 18 ...

background: metronidazole is drug of choice recommended by who for treatment of trichomoniasis, however, some reports claims drug resistance in trichomonas vaginalis isolates recently. the objective of this study was to determine the minimum lethal concentration (mlc) of metronidazole in resistant and sensitive strains, as well as genetic patterns of these stains by pcr method. methods : from f...