Sorafenib is an anticancer drug used to treat late stage kidney and liver cancer. advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). also hepatocellular (a cancer) cannot be treated with surgery certain thyroid has spread other parts body radioactive iodine. class medications called kinase inhibitors. It works by blocking action abnormal protein signals cells mult...

Presentation Incidental finding in over 50% [Novick 1999] Haematuria Loin Pain Palpable Mass Classical Triad of haematuria, loin pain, mass in 10% Paraneoplastic syndromes Hypercalcaemia (PTHrP) – seen in approximately 25% Anaemia Hyponatraemia Raised ESR Polycythaemia may be associated with inceased response to IFN Stauffer’s syndrome Abnormal LFTs Hepatic necrosis Thrombocytopenia Neutropenia...

A review of the epidemiology of renal cell cancer is presented. Risk factors for renal cell cancer such as cigarette smoking, obesity, diet, and use of analgesics and prescription diuretics are examined. Although uncommon, occupational risk factors are also reviewed. Studies examining gasoline exposure and renal cell cancer are evaluated, including investigations recently presented at a meeting...

AIM OF THE DATABASE The main purpose of the database of the Danish Renal Cancer Group (DaRenCaData) is to improve the quality of renal cancer treatment in Denmark and secondarily to conduct observational research. STUDY POPULATION DaRenCaData includes all Danish patients with a first-time diagnosis of renal cancer in the Danish National Pathology Registry since August 1, 2010. MAIN VARIABLE...

Short hairpin RNAs (shRNAs) transcribed by RNA polymerase III promoters can trigger sequence-selective gene silencing in mammalian cells. By virtue of their excellent function in knocking down expression of cancer-associated genes, shRNAs could be used as new therapeutic agents for cancer. As overexpression of Ki67 in renal cancer has been correlated to a more aggressive tumor phenotype, inhibi...

PURPOSES The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer. MATERIALS AND METHODS In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagn...

The secreted frizzled-related protein (sFRP) family plays an important role in the inhibition of the Wnt signaling pathway in various cancers. The functional significance of Wnt antagonist sFRP3 has not been investigated in renal cancer. We performed tissue microarray and found that the level of sFRP3 protein was high in normal kidney, low in primary renal cancer tissues, and high in metastatic...