نتایج جستجو برای: release floating tablet

تعداد نتایج: 262841  

2014
Gagganapalli Santhoshi Reddy Usha Yogendra Nayak Praful Balavant Deshpande Srinivas Mutalik

The present study was aimed at the development of gastroretentive floating pulsatile release tablets (FPRTs) of lercanidipine HCl to enhance the bioavailability and treat early morning surge in blood pressure. Immediate release core tablets containing lercanidipine HCl were prepared and optimized core tablets were compression-coated using buoyant layer containing polyethylene oxide (PEO) WSR co...

سعیدی, مجید, اکبری, جعفر, عنایتی فرد, رضا, چاوشیان, امید,

Background and purpose: The gastroretentive drug delivery systems can be retained in the stomach due to low bulk density. This assist in improving the oral sustained delivery of drugs that have an absorption window in a particular region of the gastrointestinal tract. These systems release the drug content before reaching the absorption site and provide optimal bioavailability. Several approach...

2010
G Vijaya Baskar N Narayanan Rajiv Gaikwad

Purpose: To develop a floating multiparticulate unit system for metoprolol tartarate, using a porous carrier, with an outcome for delayed gastric emptying. Methods: Dried microparticles of metoprolol tartarate were prepared by solvent evaporation using Eudragit ® RS-PO, polypropylene foam powder, and dichloromethane as release-rate modifying polymer, floating aid and solvent respectively. The s...

2015
Muhammad Ahsan Nasir Abbas Amjad Hussain Hamid Saeed Pervaiz Akhtar Shah Sohail Mohammad Muhammad Sohail Arshad

Purpose: To develop a zero-order sustained release floating formulation of captopril, and optimize its drug release for enhanced oral bioavailability. Methods: A relatively new approach, 3 full factorial design, was used to formulate floating captopril matrix tablets and to systematically optimize its drug release using varying levels of xanthan gum and hydroxypropyl methylcellulose (HPMC) K100...

Journal: :iranian journal of chemistry and chemical engineering (ijcce) 2015
m. christe sonia mary s. sasikumar

in the present study, floating drug delivery beads (fdds) were prepared with sodium alginate/ starch blend as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride solution as a hardening agent. in order to prepare the beads with different porosity and morphology the ratio between pore forming agent to polymer blend and ratio of the consti...

2014
Kondi Vanitha Mohan Varma Alluri Ramesh

Hydralazine hydrochloride has a half-life of 2 to 4 hours with an oral bioavailability of 26-50%. Since hydralazine has a demethylating effect on various suppressor genes, it can be used in various types of cancer to support chemotherapy. The purpose of this study was to optimize and evaluate floating tablets of hydralazine hydrochloride designed to prolong the gastric residence time and to pro...

Journal: :iranian journal of pharmaceutical sciences 0
muhammad imran faculty of pharmacy, bhauddin zakaryia university, multan, pakistan. nazar muhammad ranjha faculty of pharmacy, bhauddin zakaryia university, multan, pakistan. rao khurram ayoub faculty of pharmacy, bhauddin zakaryia university, multan, pakistan.

the main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of methocel® k15, ethocel® standard 7fp premium, eudragit ® rs100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. risperidone floating tablets were formulated by wet granulati...

2006
Shin - ichi Tomoya NAKAGAWA Yasushi SASAI Masayuki KUZUYA

method of administering therapeutic agent for their systematic effects such as patient acceptance, convenience in administration, and cost-effective manufacturing process. Thus, a wide variety of approaches of drug delivery system (DDS) have been investigated for oral application. However, the development process is precluded by several physiological difficulties, such as an inability to restra...

2013
Priyanka Shukla Ajay Yadav Rajiv Gandhi

The present study focused on the development of gastroretentive technology which will deliver the antibiotic at predetermined rate to achieve the local concentration enough to act as antibacterial against H.Pylori. This technology ensures the maximum utilization of the drug with minimum side effects and maximum patient compliance and also with reduced antibiotic resistance by the bacterium. The...

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