I develop a new empirical model for discrete games and apply it to study the release date timing game played by distributors of movies. The results suggest that release dates of movies are too clustered around big holiday weekends and that box office revenues would increase if distributors shifted some holiday releases by one or two weeks. The proposed game structure could be applied more broad...

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a sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. in this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (ec), eudragit rs100 (rs), and eudragit s100 (s) were prepared by direct compression. the release behaviors were then studied in two co...

in the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in f1 (1:0.75), f2 (1:1), f3 (1:1.5),...

hard gelatin capsule filled with acetaminophen, osmotic agent (sorbitol), a release promoter (sodium dodecyl sulfate), coated with a semipermeable cellulose acetate membrane containing a hydrophobic plasticizer (castor oil) and sealed with white bees wax plug was designed. when placed in the sink water penetrates the membrane, dissolves the osmotic agent and increases the osmotic pressure insid...

1: Ampyra (fampridine SR) Lancet. 2009 Feb 28;373(9665):732-8. Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial. Goodman AD, Brown TR, Krupp LB, Schapiro RT, Schwid SR, Cohen R, Marinucci LN, Blight AR; Fampridine MS-F203 Investigators. Collaborators: Agius M, Arnason BG, Bethoux FA, Bever CT Jr, Bowen JD, Brown TR, Dietrich DW, Edwards K, Fr...

This paper is devoted to the following version of the single machine preemptive scheduling problem of minimizing the weighted number of late jobs. A processing time, a release date, a due date and a weight of each job are given. Certain jobs are specified to be completed in time, i.e., their due dates are assigned to be deadlines, while the other jobs are allowed to be completed after their due...