Background T2* relaxometry offers a non-invasive method to accurately quantify myocardial iron levels, thus aiding the diagnosis and assessment of prognosis of patients. Two T2* sequences are used clinically: the single breathhold multi-echo gradient echo white blood (WB) and black blood (BB) techniques. At 1.5T, BB T2* has superior reproducibility and fewer artefacts than WB T2*. We compared B...

We use complementary experiments—proton NMR diffusometry and relaxometry, deuterium NMR lineshapes, and rheometry—to construct a comprehensive picture of the microscopic structure of a mixed-surfactant wormlike micellar system composed of a zwitterionic surfactant and an anionic surfactant in brine. In this system, at some surfactant concentrations, the time for micellar breaking and recombinat...

BACKGROUND Increased iron deposition has been implicated in the pathophysiology of multiple sclerosis (MS), based on visual analysis of signal reduction on T(2)-weighted images. R(2)* relaxometry allows to assess brain iron accumulation quantitatively. OBJECTIVE To investigate regional brain iron deposition in patients with a clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS)...

Anti-inflammatory therapies are the current most plausible drug candidates for anti-epileptogenesis and neuroprotection following prolonged seizures. Given that vasogenic edema is widely considered to be detrimental for outcome following status epilepticus, the anti-inflammatory agent dexamethasone is sometimes used in clinic for alleviating cerebral edema. In this study we perform longitudinal...

BACKGROUND AND PURPOSE T2 mapping is useful for identifying and quantifying abnormalities of the hippocampus and amygdala. It is particularly useful in the presurgical evaluation of patients with temporal lobe epilepsy and for the identification of bilateral hippocampal sclerosis (HS). The purpose of this study was to implement and validate a dual-echo method for producing coronal T2 maps with ...

Synopsis We describe a model-free method to quantify the spectrum of water mobilities in ៯�xed and live brain tissues. We eliminate confounds caused by anisotropic di៛�usion in brain tissues by measuring orientationally-averaged di៛�usion weighted images over a large range of b-values. Spectra of orientationally-averaged water di៛�usivities show clear distinctions between white matter, gray mat...

Potential applications of 2D relaxation spectrum NMR and MRI to characterize complex water dynamics (e.g., compartmental exchange) in biology and other disciplines have increased in recent years. However, the large amount of data and long MR acquisition times required for conventional 2D MR relaxometry limits its applicability for in vivo preclinical and clinical MRI. We present a new MR pipeli...

Fast field-cycling MRI offers access to sources of endogenous information not available from conventional fixed-field imagers. One example is the T(1) dispersion curve: a plot of T(1) versus field strength. We present a pulse sequence that combines saturation-recovery/inversion-recovery T(1) determination with field cycling and point-resolved spectroscopy localization, enabling the measurement ...