نتایج جستجو برای: relaxivity
تعداد نتایج: 880 فیلتر نتایج به سال:
BACKGROUND Liposomal-based gadolinium (Gd) nanoparticles have elicited significant interest for use as blood pool and molecular magnetic resonance imaging (MRI) contrast agents. Previous generations of liposomal MR agents contained gadolinium-chelates either within the interior of liposomes (core-encapsulated gadolinium liposomes) or presented on the surface of liposomes (surface-conjugated gad...
Combining sugar conjugates and DO3A-Gd complexes, paramagnetic gold glyconanoparticles (GNPs) with different relaxivity values were obtained and tested in vivo as MRI probes.
Macromolecular contrast agents have the potential to assist magnetic resonance imaging (MRI) due to their high relaxivity, but are not clinically useful because of toxicity due to poor clearance. We have prepared a biodegradable ketal-based polymer contrast agent which is designed to degrade rapidly at physiological pH by hydrolysis, facilitating renal clearance. In vitro, the agent degraded mo...
The objective of this work was the synthesis of serum albumin targeted, Gd(III)-based magnetic resonance imaging (MRI) contrast agents exhibiting a strong pH-dependent relaxivity. Two new complexes (Gd-glu and Gd-bbu) were synthesized based on the DO3A macrocycle modified with three carboxyalkyl substituents α to the three ring nitrogen atoms, and a biphenylsulfonamide arm. The sulfonamide nitr...
Integration of optical and magnetic resonance imaging (MRI) methods in one setting is appealing due to the complementary nature of MRI’s high spatial and temporal resolution and the high molecular sensitivity of optical imaging. In particular, deep tissue penetration of near-infrared (NIR) photons and minimal autofluorescence in this wavelength range favors the assessment of molecular events in...
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