PURPOSE The aim of this study was to assess the pharmacophysiological significance of the enteric nervous system for the mechanical responses of lower esophageal sphincter (LES) in infantile rats with kaolin-induced hydrocephalus. MATERIAL AND METHODS Hydrocephalus was created in 7-day-old rats by injection of kaolin into the cisterna magna. After 10 days, rats were decapitated. Contractile (...

Objective: The study was done to evaluate the antiasthma activity of Macerated and Soxhlet extracts of (pulp) of plant Liomnia acidissima Linn on tracheal chains of guinea pigs. Methods: The (pulp) of fruits of plant Liomnia acidissima Linn was extracted with 95% ethanol at 55oC and evaluate for their antiasthma activity on tracheal chains of guinea pigs by using three cumulative concentrations...

Objective(s): Baicalein, a compound extracted from a variety of herbs, showed various pharmacological effects. This study evaluated the relaxant effects of baicalein and its underlying molecular mechanisms of action on rat’s isolated tracheal smooth muscle.Materials and Methods: Tracheal smooth muscle were contracted by 10 μM methacholin...

Increasing epidemiological evidence supports the view, that quercetin has protective roles in a multitude of disease states in human who have a high intake of polyphenols. To investigate the ability of quercetin and its rutinoside, rutin, to modulate the relaxation of human airways smooth muscle and to determine the mechanism (s) of such relaxation, isolated human bronchus rings were suspended ...

The ability of forskolin and isoproterenol to inhibit the contractile action of the muscarinic agonist, oxotremorine-M, was investigated in smooth muscle from wild-type and M(2) muscarinic receptor knockout mice. Forskolin (5.0 micro M) caused a significant reduction in the contractile activity of oxotremorine-M in ileum, trachea, and urinary bladder from both wild-type and M(2) muscarinic rece...

I originally took a muscle relaxer because I was experiencing very bad back pain and could not sleep. I was not prescribed the muscle relaxers. My friend suggested I take one of hers. So I did, and now I will take one sometimes before bed if I can't fall asleep or if I want to actually just relax. It makes me just want to sleep, and I feel really calm after taking one. Is this bad that I take t...

Corresponding author: Dr Arsen Uvelin, M.D. Clinical centre of Vojvodina, Emergency Centre, Department of Anaesthesia and Intensive Therapy Hajduk Veljka 1, 21000 Novi Sad, Serbia e-mail: [email protected] Sir, the “timing principle” utilises administration of a single bolus dose of nondepolarizing muscle relaxant (NMR), followed by an induction drug at the onset of muscular weakness (1) was...

The gasotransmitter nitric oxide was classified as the first endothelium-derived relaxant factor, and opened a new era in cardiovascular research. Another small gas, sulfur dioxide (SO₂), can also be generated endogenously in mammals. Recent studies have shown that SO₂ may play important roles in the cardiovascular system. At low concentrations, the vasodilatory effect of SO₂ is endothelium-dep...

The flexible laryngeal mask airway (FLMA) is becoming more and more popular in general anesthesia during surgery of head, neck and upper chest. But very limited information has been published about whether muscle relaxant was necessary or not for anesthesia with FLMA. To investigate whether low-dose muscle relaxant is necessary in preventing ventilation leak of FLMA in radical mastectomy, forty...

Correspondence: Sorin J Brull Department of Anesthesiology, Mayo Clinic College of Medicine, 4500 San Pablo road, Jacksonville, FL 32224, USA Tel +1 904 956 3331 Fax +1 904 956 3332 email [email protected] Abstract: Despite the significant improvements in the pharmacology of muscle relaxants in the past six decades, the search for the ideal muscle relaxant continues, mainly because of the inc...