Reference interval limits for cancer biomarkers in geriatrics are rare because priority is given to the development of reference those age range 18–60 years, which normally used clinical trials study. The aim this study was therefore develop gender and age-specific markers CA19-9, CEA, CA 15-3, 125, PSA adults Taita-Taveta County, Kenya, using CLSI CA28-A3 guideline. This prospective cross-sect...

BACKGROUND This study was performed to establish age-related serum reference intervals for procollagen type I N-propeptide (P1NP) and type I collagen C-telopeptide (CTx) in the Australian population. METHODS Fasting sera from 1143 males (mean age 60 years; range 20-97 years) and 1246 females (mean age 53 years; range 20-93 years) who participated in the Geelong Osteoporosis Study were analyse...

We describe a novel magnetic-separation microencapsulated antibody displacement assay for free thyroxin. The method is rapid (results available in just over an hour), with a detection limit of 3 pmol/L, and an interassay precision of less than 10% over the range 8-75 pmol/L. Results are not influenced by changes in the concentration of thyroxin-binding globulin or albumin, nor by the presence o...

Biases such as the preference of a particular response for no obvious reason, are an integral part of psychophysics. Such biases have been reported in the common two-alternative forced choice (2AFC) experiments, where participants are instructed to compare two consecutively presented stimuli. However, the principles underlying these biases are largely unknown and previous studies have typically...

A two interval forced choice constant stimuli method was used to determine: (i) the point of subjective equality (PSE); and (ii) the just-noticeable-difference (JND) in contrast for two luminance gratings, one held in short-term visual memory. Psychometric functions for delayed contrast discrimination were determined as a function of spatial frequency from 1 to 8 c/deg, reference contrast from ...

A full-term baby boy underwent an ultrasound scan of the abdomen at 6 weeks of age for the follow-up of an antenatal diagnosis of left-sided hydronephrosis. Although there was no hydronephrosis, the abdominal ultrasound revealed an enlarged liver with multiple hypoechoic lesions measuring up to 25 mm in diameter. He was admitted to the hospital for further evaluation of the hepatic lesions. Exa...

A previously healthy 4-year-old girl presented with a 2-day history of severe nausea, vomiting, and diarrhea. Her symptoms began with diffuse abdominal pain followed by alternating episodes of vomiting and nonbloody diarrhea. There were no reports of sick contacts, recent travel, camping, or unusual food or water consumption. On the first day of symptoms, her primary care physician diagnosed vi...