in this work, quantitative structure-property relationship (qspr) approaches were used to predict the redox potential of 42 phenolic antioxidants. the structures of all compounds optimized by the am1 semi-empirical method and then a large number of molecular descriptors were calculated for each compound in the data set. subsequently, stepwise multilinear regression was applied to select the mos...

modification of natural polymers like protein by graft co-polymerization is an important method to incorporate the desired properties into the backbone. soy protein concentrate (spc) was grafted with ethylmethacrylate (ema) using ascorbic acid /potassium persulphate as redox initiator system under pressure. different reaction parameters such as reaction time, reaction pressure, solvent amount, ...

Excessively generated reactive oxygen species are associated with age-related neurodegenerative diseases. We investigated whether scavenging of reactive oxygen species in the brain by orally administered redox nanoparticles, prepared by self-assembly of redox polymers possessing antioxidant nitroxide radicals, facilitates the recovery of cognition in 17-week-old senescence-accelerated prone (SA...

Responses to many growth and stress conditions are assumed to act via changes to the cellular redox status. However, direct measurement of pH-adjusted redox state during growth and stress has never been carried out. Organellar redox state (E GSH) was measured using the fluorescent probes roGFP2 and pHluorin in Saccharomyces cerevisiae. In particular, we investigated changes in organellar redox ...

The redox state, like the pH or the osmotic pressure, represents chemical characteristics of the intracellular environment. The intracellular redox homeostasis can be disturbed by the installation of the “oxidative stress”, which manifests itself through the dysregulation of the balance between the systems that produce oxidant agents and the antioxidant defense mechanisms (the redox balance). E...

In many physiological contexts, intracellular reduction-oxidation (redox) conditions and the unfolded protein response (UPR) are important for the control of cell life and death decisions. UPR is triggered by the disruption of endoplasmic reticulum (ER) homeostasis, also known as ER stress. Depending on the duration and severity of the disruption, this leads to cell adaptation or demise. In thi...

Redox homeostasis is a fundamental property of living cells and actively responds to cellular metabolism and external stimuli. In all cells, small molecules capable of thiol-disulphide exchange such as glutathione (GSH) are abundant and are thought to act as buffers in redox equilibrium [1]. Given the importance and the general interest in cellular redox processes, a noninvasive method that det...

Introduction Prokaryotes must cope with oxidative stress as a result of the normal aerobic metabolism as well as a consequence of exogenous drugs, radiations or even infection-derived host defences. Oxidative stress is responsible for damaging essential cellular structures and biomolecules such as DNA, lipids or proteins. Intriguingly, some transcriptional regulators are capable to sense those ...

Cells and tissues must maintain a reducing environment to survive. This reducing environment provides the electrochemical gradient needed for electron flow. This movement of electrons provides the energy needed to build and maintain cellular structures and associated functions. An array of redox couples is responsible for the electron transfer. Some of these redox couples are linked to each oth...

In cystic fibrosis reduced CFTR function may alter redox properties of airway epithelial cells. Redox-sensitive GFP (roGFP1) and imaging microscopy were used to measure the redox potentials of the cytosol, endoplasmic reticulum (ER), mitochondria, and cell surface of cystic fibrosis nasal epithelial cells and CFTR-corrected cells. We also measured glutathione and cysteine thiol redox states in ...