Production of reticulocytes All blood cells emanate from a stem cell. Under pronounced proliferation they differentiate into cells of the three blood cell lines (erythropoiesis, granulopoiesis and thrombopoiesis). Focusing on the red blood cell (RBC) line, we see that the life span of circulating erythrocytes is approx. 120 days. Nearly 1 % of this total is lost daily and is replenished by new ...

background: blood is permanently exposed to oxidation stress and therefore has a high antioxidants capacity. many different factors increasing the demand for the antioxidant capacity can be observed in the stored blood of donors. consequently, damage to erythrocytes by free radicals may occur. so it is useful to control the alternation of anti-oxidant enzymes in stored blood at different days o...

A spring model is applied to simulate the skeleton structure of the red blood cell (RBC) membrane and to study the red blood cell (RBC) rheology in microvessels. The biconcave RBC shape in static plasma and tank-treading behavior of single cell in shear flows have been successfully captured in this model. The behavior of the RBC in a Poiseuille flow and the lateral migration of the cells in a s...

Anaemia in intensive care is common, with approximately 50% of patients receiving a red cell transfusion. Recognised complications from transfusion include 'transfusion associated lung injury', infection, and organ failure progression. Most cohort studies show a positive relationship between red cell transfusion and adverse outcomes. In 2012, the British Committee for Standards in Haematology i...

The changes in the osmotic resistance of red blood cells (RBC), due to various pathological conditions like exposure to heat, anemia as well as the effect of storage and anticoagulants have been investigated. The results have shown that exposure to a temperature of 50 degrees C makes the red blood cells fragile to osmotic pressures. Also, red blood cells from the patients suffering from anemia ...

Background Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components that accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ injury in transfused patients. Methods Cardiac surgery patients at increased risk of large-volume RBC transfusion were eligible. Participants were randomized to receive either me...

To evaluate the role of red blood cell (RBC) antioxidants as clinical markers of oxidative exposure, we measured RBC glutathione (GSH) concentrations in 32 adult patients with cystic fibrosis (CF), and 8 healthy age-matched control subjects. We chose patients with CF because this disease is characterized by severe bronchial inflammation and marked oxidant-antioxidant imbalance. Although the GSH...

Many different factors influence the propensity of transfusion recipients and pregnant women to form red blood cell alloantibodies (RBCA). RBCA may cause hemolytic transfusion reactions, hemolytic disease of the fetus and newborn and may be a complication in transplantation medicine. Antigenic differences between responder and foreign erythrocytes may lead to such an immune answer, in part with...