BACKGROUND Approximately 205 million pregnancies occur each year in the worldwide. On the other hand, Spontaneous abortion has been reported in 15-20% of all diagnosed pregnancies. The most common cause of spontaneous abortion is chromosomal abnormalities of the embryo. Robertsonian translocation carriers specially 21-14 are the most common balanced rearrangement among the carrier couples with ...

Spontaneous abortion is the most common complication of pregnancy. Immune activation and the subsequent inflammation-induced tissue injury are often observed at the maternal-fetal interface as the final pathological assault in recurrent spontaneous abortion. However, the precise mechanisms responsible for spontaneous abortion involving inflammation are not fully understood. Chemokine CCL28 and ...

Massive chronic intervillositis (MCI) is an unusual placental lesion associated with poor fetal growth and adverse pregnancy outcome; it has not previously been associated with spontaneous abortion or recurrent pregnancy loss. This article reports a patient who had 10 spontaneous abortions with repetitious massive chronic intervillositis documented in four of five gestations spanning all three ...

Background: The maximum probability of conceiving during a menstrual cycle is only about 40%. One third of conceptions do not result in the delivery of a baby recurrent miscarriage, defined as the loss of 3 or more pregnancies before 20 weeks post-menstruation that affects 1% of all women. Approximately 20 percent of pregnant women will have some bleeding before 20 weeks’ gestation, and roughly...

OBJECTIVE A case-control study was undertaken to assess the association between an estrogen receptor gene variant and the risk of recurrent spontaneous abortions. STUDY DESIGN The frequency of the estrogen receptor gene variant in blood lymphocyte deoxyribonucleic acid and other selected maternal characteristics was compared among 60 primary recurrent aborters, 61 secondary recurrent aborters...

BACKGROUND Different studies show that chromosomal balance translocation in the parents can cause recurrent spontaneous abortions. Incidence of chromosomal translocation abnormalities in couples with repeated abortions is from 0% to 31%. OBJECTIVE The purpose of this research was studying the presence or absence of chromosomal abnormalities and heteromorphism in couples with recurrent abortio...

background: human peripheral blood nk cells constitutively express cd56 and cd16 antigens. peripheral blood nk cells seem to be strongly related with decidual nk cells, and may reflect the decidual nk cell functional status. there are varied reports concerning the relationship between nk cell cytotoxicity in women with recurrent spontaneous abortion. objective: to study nk activity in women wit...

BACKGROUND: Several humoral immune factors are responsible for a successful pregnancy. There are a few studies, which demonstrate the role of antipaternal cytotoxic antibodies (APCA) and mixed lymphocyte reaction blocking factor (MLR-Bf) in the maintenance of pregnancy. However, these factors have not been studied in women with history of recurrent spontaneous abortion (RSA). We designed this s...