QUESTION One of my patients is a pregnant woman in her first trimester with a history of recurrent genital herpes. She is concerned about whether use of her antiviral medication will adversely affect her baby. What should I tell her? ANSWER Studies have shown that the use of acyclovir or valacyclovir is not associated with an increase in birth defects. Limited data exist for famciclovir and t...

OBJECTIVE To compare the efficacy and safety of oral acyclovir (400 mg twice daily) with oral isoprinosine (500 mg twice daily) in the suppression of recurrent genital herpes. DESIGN Double-blind, double-dummy, randomised, controlled, parallel group trial. SETTING 13 centres in UK, Belgium and Germany. SUBJECTS 127 immunocompetent patients with frequently recurring genital herpes. MAIN ...

Genital herpes is a risk factor to acquire HIV-1 infection by sexual contact, by increasing both infectivity of an infected person and susceptibility to acquire HIV-1. Here we have investigated the mechanisms that underlie the increased susceptibility to HIV-1 when people have genital herpes. Under steady state conditions, LCs capture HIV-1 through interaction with the C-type lectin Langerin, r...

Genital herpes is one of the most prevalent sexually transmitted infections in both the developing and developed world. Following infection, individuals experience life-long latency associated with sporadic ulcerative outbreaks. Despite many efforts, no vaccine has yet been licensed for human use. Herein, we demonstrated that nasal immunization with an adjuvanted HSV-2 gD envelope protein mount...

OBJECTIVES To determine the etiology and factors associated with genital ulcer disease (GUD) among patients presenting to a sexually transmitted infections clinic in Manaus, Brazil; and to compare a multiplex polymerase chain reaction (M-PCR) assay for the diagnosis of GUD with standard methods. METHODS Ulcer swabs were collected and used for Tzanck test and processed in an M-PCR to detect he...

introduction: herpes labialis is important in dentistry because of its high prevalence. herpes simplex virus (hsv) is responsive to treatment and infection control methods help protect patients and dental personnel. due to high levels of stress in the flight crew this study evaluated the prevalence of recurrent herpes labialis in the personnel of an airline company. materials and methods: in th...

Incidence of reported cases genital herpes in different countries has increased dramatically during the last years, which is essentially caused by spread asymptomatic or atypical types herpes. Frequent relapses infection are characterized changes immunological status. The authors presented article analysed findings foreign and domestic studies on treatment disease, systematized information abou...

BACKGROUND/OBJECTIVES While nearly one in four Americans has antibodies to HSV-2, only one of 40 reports a history of genital herpes (GH). The goal of this study was to correlate questions designed to elicit a GH history with serological evidence of HSV-2 in male STD clinic attendees. METHODS Consecutive males were enrolled in a study of the epidemiology of GH. Consenting men answered questio...