Aim: To compare the transanal suture rectopexy with stapled haemorrhoidopexy in patients of haemorrhoids from clinical perspective. Methods: From January 2014 to January 2016, Eighty patients of haemorrhoids from grade II to IV were randomly assigned to undergo either the transanal suture rectopexy (n= 40) or the stapled haemorrhoidopexy (n=40). Outcome assessment was performed at 12 hours,24 h...

Class of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), includes Anaprox (naproxen), Ansaid (flurbiprofen), Arthrotec (diclofenac sodium/misoprostil), Caldolor (ibuprofen), Cambia (diclofenac potassium), Cataflam (diclofenac), Celebrex (celecoxib), Daypro (oxaprozin), Daypro Alta (oxaprozin), Duexis (ibuprofen and famotidine), Dyloject (diclofenac), Feldene (piroxicam), Flector (diclofenac), In...

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class with anti-inflammatory, analgesic, and antipyretic properties. Contrary to the action of many traditional NSAIDs, diclofenac inhibits cyclooxygenase (COX)-2 enzyme with greater potency than it does COX-1. Similar to other NSAIDs, diclofenac is associated with serious dose-dependent gastrointestinal, cardi...

Degradation reactions on diclofenac-monoglycerides (3a,b), diclofenac-(p-hydroxybenzoate)-2-monoglyceride (3c), diclofenac (1), and diclofenac lactam (4) were performed at 37 °C in isotonic buffer solutions (apparent pH range 1-8) containing varying concentrations of acetonitrile (ACN). The concentration remaining of each analyte was measured versus time. Diclofenac-monoglycerides and diclofena...

results twelve original studies fulfilled the inclusion criteria. the current literature suggests that the learning curve of robotic rectal surgery varies between 15 and 44 cases and is probably shorter to that of laparoscopic rectal surgery. conclusions there are only a few studies assessing the learning curve of robotic rectal surgery and they possess several differences in methodology and ou...

A total of 30 Nigerian indigenous male dogs aged 1-2 years (1.65±0.47) and 11-15kg (13.4±1.27) body weight were used for the study. They randomly allocated into 6 groups 5 each. Groups A1, B1 C1 intramuscular at 2mg/kg, 3mg/kg 4mg/kg respectively A2, B2 C2 per-rectal 2mg//kg, 4mg/kg. Haematological values Packed cell volume (PCV), haemoglobin (Hb), Red blood (RBC), White (WBC) Differential leuc...

Objectives: Renal colic is a type of abdominal pain commonly caused by obstructive stones. The aim of this study was to compare the safety and efficacy of rectal diclofenac sodium (RDS) and intramuscular pethidine (IMP) injection in acute renal colic. Materials and Methods: In an interventional prospective double-blind randomized clinical trial, 541 patients who had referred to our center becau...

Diclofenac is a widely used analgesic drug that can cause serious adverse drug reactions. We used Saccharomyces cerevisiae as a model eukaryote with which to elucidate the molecular mechanisms of diclofenac toxicity and resistance. Although most yeast cells died during the initial diclofenac treatment, some survived and started growing again. Microarray analysis of the adapted cells identified ...

Poor penetration of diclofenac through in vitro rat dorsal skin including subcutaneous tissue was observed. The poor penetration of diclofenac seemed to be predominIntly due to the poor permeability of the stratum corneum. Hydrogenated soya phospholipids (phospholipid) in aqueous gel form increased the penetration of diclofenac in the in vitro study, by increasing diclofenac transport through t...