نتایج جستجو برای: recruitment

تعداد نتایج: 62776  

Journal: :The Journal of Biological Chemistry 2009
J. Michael Elliott Lionel Rouge Christian Wiesmann Justin M. Scheer

One key event in inflammatory signaling is the activation of the initiator caspase, procaspase-1. Presented here is the crystal structure of the procaspase-1 zymogen without its caspase recruitment domain solved to 2.05 A. Although the isolated domain is monomeric in solution, the protein appeared dimeric in crystals. The loop arrangements in the dimer provide insight into the first autoproteol...

Journal: :NeuroImage 2017
Peggy St. Jacques Karl Szpunar Daniel L. Schacter

The dynamic and flexible nature of memories is evident in our ability to adopt multiple visual perspectives. Although autobiographical memories are typically encoded from the visual perspective of our own eyes they can be retrieved from the perspective of an observer looking at our self. Here, we examined the neural mechanisms of shifting visual perspective during long-term memory retrieval and...

Journal: :Psychiatry research 2012
Olivier Le Bon Daniel Neu Yves Berquin Jean-Pol Lanquart Robert Hoffmann Olivier Mairesse Roseanne Armitage

The role of sleep in patients diagnosed with chronic fatigue syndrome is not fully understood. Studies of polysomnographic and quantitative sleep electroencephalographic (EEG) measures have provided contradictory results, with few consistent findings in patients with Chronic Fatigue Syndrome (CFS). For the most part, it appears that delta EEG activity may provide the best discrimination between...

Journal: :Nature Biotechnology 2002

Journal: :Dermatology Online Journal 2016

Journal: :Nursing Management 2008

Journal: :Science 1967

2014
Aaron M. Ver Heul Lokesh Gakhar Robert C. Piper Ramaswamy Subramanian

The Caspase Recruitment Domain (CARD) from the innate immune receptor NOD1 was crystallized with Ubiquitin (Ub). NOD1 CARD was present as a helix-swapped homodimer similar to other structures of NOD1 CARD, and Ub monomers formed a homodimer similar in conformation to Lys48-linked di-Ub. The interaction between NOD1 CARD and Ub in the crystal was mediated by novel binding sites on each molecule....

Journal: :Journal of neurophysiology 2006
Arthur Wingfield Murray Grossman

Human aging brings with it declines in sensory function, both in vision and in hearing, as well as a general slowing in a variety of perceptual and cognitive operations. Yet in spite of these declines, language comprehension typically remains well preserved in normal aging. We review data from functional magnetic resonance imaging (fMRI) to describe a two-component model of sentence comprehensi...

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