BACKGROUND Red blood cells (RBC) possess a nitric oxide synthase (RBC-NOS) whose activation depends on the PI3-kinase/Akt kinase pathway. RBC-NOS-produced NO exhibits important biological functions like maintaining RBC deformability. Until now, the cellular target structure for NO, to exert its influence on RBC deformability, remains unknown. In the present study we analyzed the modification of...

We report a three-phase bone scintigraphy for the diagnosis of a peripheral bone lesion caused by systemic sarcoidosis. A 32-year-old man with suspected osteomyelitis of the right forefinger underwent three-phase bone scintigraphy with Tc-99m hydroxymethylene diphosphonate (HMDP) and single-photon emission computed tomography/computed tomography (SPECT/CT). The lesion was rich in blood flow acc...

BACKGROUND Duarte galactosemia (DG) is frequently detected in newborn-screening programs. DG patients do not manifest the symptoms of classic galactosemia, but whether they require dietary galactose restriction is controversial. We sought to assess the relationships of selected galactose metabolites (plasma galactose, plasma galactitol, erythrocyte (RBC) galactitol, RBC galactonate, and urine g...

Sensitivity to rubella virus hemagglutination differs considerably with newborn as opposed to adult erythrocytes (RBC) in several animal species. In humans, cord RBC are 16 times more sensitive to hemagglutination, whereas hemagglutination titers with newborn RBC are 6 to 16 times higher in chickens, mice, and rabbits. This higher sensitivity is, however, short-lived, and adult RBC values are o...

The syndrome of disseminated intravascular coagulation (DIC) 1 is a recognized complication of acute hemolytic episodes in both man (1-3) and laboratory animals (4, 5) and has been induced experimentally in monkeys and dogs by infusion of autologous red blood cell stroma (6, 7). The mechanism of stromainduced D I C may be analogous to the demonstrable procoagulant activity of red cell membrane ...

We present results for the leading hadronic contribution to the muon anomalous magnetic moment due to strange quark-connected vacuum polarisation effects. Simulations were performed using RBC–UKQCD’s Nf = 2 + 1 domain wall fermion ensembles with physical light sea quark masses at two lattice spacings. We consider a large number of analysis scenarios in order to obtain solid estimates for residu...

Erythrocytes (RBC) from untrained male Wistar rats and rat glomerular endothelial cells (EC) were used to investigate the effects of acute exercise (speed: 20 m/min, slope: 0, duration: 1 hour) on RBC membrane protein oxidation and adhesion to cultured EC. Experimental animals were divided into juvenile (age 10 weeks) and adult (age 30 weeks) groups for these studies. Immediately following exer...

The vasoocclusive process in patients with sickle cell disease (SCD) is complex and involves interactions among sickle erythrocytes (SS-RBC), vascular endothelium, and plasma and cellular components. The role of neutrophils (PMN) in vasoocclusion has not been examined. Patients with SCD appear to have chronically activated PMN. Because the first step in PMN activation is particle recognition, w...

1.5 Range of Application, Dosage, Mode of Administration 1.5.1 Indications 1.5.1.1 General Principles 1.5.1.2 Acute Blood Loss 1.5.1.3 Chronic Anemias 1.5.2 Indications for Special RBC Concentrates 1.5.2.1 Irradiated Leukocyte-Depleted RBC Concentrates 1.5.2.2 Washed RBC Concentrates 1.5.2.3 Cryopreserved RBC Concentrates 1.5.2.4 CMV and Parvovirus B19 1.5.3 Selection and Dosage of RBC Concentr...

1.5 Range of Application, Dosage, Mode of Administration 1.5.1 Indications 1.5.1.1 General Principles 1.5.1.2 Acute Blood Loss 1.5.1.3 Chronic Anemias 1.5.2 Indications for Special RBC Concentrates 1.5.2.1 Irradiated Leukocyte-Depleted RBC Concentrates 1.5.2.2 Washed RBC Concentrates 1.5.2.3 Cryopreserved RBC Concentrates 1.5.2.4 CMV and Parvovirus B19 1.5.3 Selection and Dosage of RBC Concentr...