background: ischemia reperfusion (ir) is the main pathology of torsion of testis and it is a common urologic emergency. there is some evidence that shows oxytocin (ot) plays role in ischemia reperfusion. objective: to evaluate this hypothesis that ot can decrease germ cell apoptotic index in testis under acute ischemia reperfusion in a rat model. materials and methods: 20 adult rats were random...

PURPOSE Estradiol (E2) modulates testicular functions including steroidogenesis, but the mechanisms of E2 signaling in human testis are poorly understood. GPER-1 (GPR30), a G protein-coupled membrane receptor, mediates rapid genomic and non-genomic response to estrogens. The aim of this study was to evaluate GPER-1 expression in the testis, and its role in estradiol dependent regulation of ster...

Induction of mesothelioma in the rat is an important animal model for assessing the carcinogenic potential of fibers and for understanding the molecular basis underlying the development of these tumors. Mesotheliomas and nephroblastoma (Wilms' tumor) have many developmental, biochemical, and histological similarities; however, the expression of the Wilms' tumor suppressor gene, WT-1, has not be...

Background: In infertility clinics, biopsies taken from undescended atrophic testicles showed increased mast cells which are not found in normal testis. So, it was thought that could have a contributing effect on fibrosis leading to testicular atrophy. Our aim of the study is investigate efficacy ketotifen, cell stabilizer, prevention torsion-detorsion rat model. Materials and Methods: Thirty r...

BACKGROUND Phthalate exposure induces germ cell effects in the fetal rat testis. Although experimental models have shown that the human fetal testis is insensitive to the steroidogenic effects of phthalates, the effects on germ cells have been less explored. OBJECTIVES We sought to identify the effects of phthalate exposure on human fetal germ cells in a dynamic model and to establish whether...