Large well-designed clinical efficacy and safety randomized clinical trials (RCTs) are required to achieve regulatory approval of new drug treatments. The objective of this article is to make recommendations for the criteria for defining and selecting the clinical trial study population, design and efficacy outcomes measures which comprise ideal premature ejaculation (PE) interventional trial m...

Background: There is ongoing debate regarding the usefulness of laparoscopic pancreaticoduodenectomy. This study aimed to analyze all randomized control trials published including most recent one.

Be honest – what is easier to publish: in vitro or clinical research? But let’s start from the beginning. The “pyramid of evidence” ranks like this: 1a: Systematic reviews (with homogeneity) of randomized controlled trials 1b: Individual randomized controlled trials (with narrow confidence interval) 1c: All randomized controlled trials (or none) 2a: Systematic reviews (with homogeneity) of coho...

OBJECTIVE To systematically review the randomized trials, observational studies, and survey evidence on compression and pneumatic devices for thromboprophylaxis in intensive care patients. METHODS Published studies on the use of compression and pneumatic devices in intensive care patients were assessed. A meta-analysis was conducted by using the randomized controlled trials. RESULTS A total...

OBJECTIVE To determine how well therapeutic randomized controlled trials (RCTs) in the Journal of Pediatric Psychology (JPP) met the CONSORT criteria as compared to pediatric trials in the Journal of Clinical and Consulting Psychology (JCCP), which served as a control. METHODS Nine trials were found in JPP and 19 clinical trials were retrieved from JCCP. The modified Consort Checklist and Flo...

At more than 10 years after the paper by Hotopf and colleagues regarding pragmatic trials in psychiatry, the field has evolved and is evolving further. There have been many developments in our understanding of what pragmatism really means, and excellent examples of truly pragmatic trials in psychiatry are currently available. Funders have helped encourage more emphasis on the need for such stud...