Raman spectroscopy is a facile method that can be used to analyze a wide variety of samples, such as materials pertaining to life sciences and healthcare, like pharmaceuticals and biological materials, to high technology nanomaterials such as graphene and carbon nanotubes. Many analytical challenges exist when analyzing the aforementioned samples, such as a requirement for high spatial resoluti...

Raman spectroscopy provides label-free biochemical information from tissue samples without complicated sample preparation. The clinical capability of Raman spectroscopy has been demonstrated in a wide range of in vitro and in vivo applications. However, a challenge for in vivo applications is the simultaneous excitation of auto-fluorescence in the majority of tissues of interest, such as liver,...

Microalgae are extensively researched as potential feedstocks for biofuel production. Energy-rich compounds in microalgae, such as lipids, require efficient characterization techniques to investigate the metabolic pathways and the environmental factors influencing their accumulation. The model green alga Coccomyxa accumulates significant amounts of triacylglycerols (TAGs) under nitrogen depleti...

Raman spectroscopy has undergone a technical revolution during the last fifteen years. Following a brief introduction to the physical principles we present recent applications to materials of technological interest. Nearinfrared excitation, in particular, offers the ability to measure the Raman spectrum in the absence of undesired absorption and photoreactions. The combination of Raman spectros...

We designed an arrayed-waveguide grating spectrometer for the detection of early dental caries in teeth through polarized Raman spectroscopy. Measurement results on extracted human teeth demonstrate the feasibility of the approach. (Abstract) Keywords-component; Raman spectroscopy; integrated optics;

Raman spectroscopy and surface enhanced Raman spectroscopy (SERS) have many attributes that make them attractive for field detection of environmental contaminants, industrial process control, as well as materials detection/identification in agriculture, pharmaceuticals, law enforcement/first responders, geology, and archeology. However, portable, robust, inexpensive Raman systems are required f...

Fast and sensitive Raman spectroscopy measurements are imperative for a large number of applications in biomedical imaging, remote sensing and material characterization. Stimulated Raman spectroscopy offers a substantial improvement in the signal-to-noise ratio but is often limited to a discrete number of wavelengths. In this report, by introducing an electronically-tunable acousto-optical filt...

Optical spectroscopy and imaging methods have proved to have potential to discriminate between normal and abnormal tissue types through minimally invasive procedures. Raman spectroscopy and Optical Coherence Tomography (OCT) provides chemical and morphological information of tissues respectively, which are complementary to each other. When used individually they might not be able to obtain high...

The effect of chemical composition on the Raman spectra of a series of natural calcalkaline silicate glasses has been quantified by performing electron microprobe analyses and obtaining Raman spectra on glassy filaments (~450 µm) derived from a magma mingling experiment. The results provide a robust compositionally-dependent database for the Raman spectra of natural silicate glasses along the c...