Metastatic castration-resistant prostate cancer (mCRPC) frequently metastasizes to the bone, often resulting in painful skeletal events, reduced quality of life, and reduced survival. The beta-emitting radiopharmaceuticals strontium-89 and samarium-153 alleviated pain in mCRPC patients with widespread skeletal metastases and have been associated with myelotoxicity. Radium-223, a first-in-class ...

INTRODUCTION A number of drugs have been shown to extend life expectancy in castration-resistant prostate cancer (CRPC). Skeletal related events (SREs) secondary to bone metastases cause significant morbidity for men with CRPC. The α-emitting radiopharmaceutical radium-223 dichloride has been shown to improve overall survival, time to symptomatic skeletal events (SSEs) and quality of life in CR...

After practicing medicine for two years, he entered graduate school and in May 2005 received his Ph.D. in Biochemistry and Molecular Genetics at the University of Alabama at Birmingham. He is currently a research associate at the University of Wisconsin-Madison. He is the recipient of the American Medical Association's Physican's Recognition Award and was also recipient of the Outstanding Gradu...

INTRODUCTION Approximately 10 - 20% of prostate cancer cases ultimately progress to castration-resistant prostate cancer (CRPC), for which there is a poor prognosis and a therapeutic need. Radium-223 dichloride (radium-223 [Xofigo]) is a first-in-class α-emitting radiopharmaceutical shown to significantly prolong overall survival in patients with CRPC with symptomatic bone metastases and no vis...

INTRODUCTION Bone seeking radiopharmaceuticals have been used for decades in the palliation of pain from bone metastases emerging from prostate cancer. Recent clinical evidence has demonstrated an improved survival in men with metastatic castration resistant prostate cancer (CRPC) with radium 223. MATERIAL AND METHODS A review of the literature was performed to identify the role of radiopharm...

This study aims to assess the environmental hazards from radon exhalation rate in the soil samples in selected locations in Iraqi Kurdistan, using passive (CR-39NTDs) and active (RAD7) detecting method. Radon concentration, effective radium content and radon exhalation rate were estimated in soil samples that collected at the depth level of 30 cm inside 124 houses. The results show that the ema...

We used two short-lived radium isotopes (223Ra, 224Ra) and a mass balance approach applied to the radium activities to determine the nutrient contribution of saline submarine groundwater discharge to the coastal waters of the northern Gulf of Aqaba (Israel). Radium isotope activities were measured along transects during two seasons at a site that lacked any obvious surficial water input. An ons...

Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer. Different radionuclides that emit β-rays such as (153)Samarium and (89)Strontium and achieve palliation are commercially available. In contrast to β-emitters, (223)Radium as a α-emitter has a short path-length. The advantage of the α-emitter is thus a highly loca...

Background: Radon is an odourless, colourless and tasteless gas and it is the first cause of lung cancer among non- smokers. The assessment of the level of radium in building materials helps in understanding the radiological implications. It has been observed that everyone has some levels of exposure to them. Therefore measurement of radium and radon in the soil samples are important f...

Problem statement: Uranium is a radiotoxic element found in trace quantities in alomost all natural accurring materials like soil, rock. Radon an inert radioactive gas whose predecessor in uranium, is emitted from soil beneath the house and from building materials. Accurate knowledge of exhalation rate plays an important role in characterization of the radon source strength in some building mat...