Background Baseline clinical variables are prognostic for overall survival (OS) in patients with castration-resistant prostate cancer (CRPC). Their prognostic and predictive value with agents targeting bone metastases, such as radium-223, is not established. Patients and methods The radium-223 ALSYMPCA trial enrolled patients with CRPC and symptomatic bone metastases. Prognostic potential of ...

abstract background: the radiological impact of the use of phosphate fertilizers in soil is due to the internal irradiation of the lung by the alpha particles, short lived radon-thoron progeny and the external irradiation of the body by gamma rays emitted from radionuclides in situ. this paper describes the results of gamma spectrometric measurements of the concentration of the natural radionuc...

Becquerell has observed that p-rays change yellow phosphorus into red form. Ramsey* and Cameron* have shown that the radium emanation has destruotive and partial synthetic actions upon water, carbon monoxide, carbon dioxide, hydrogen chloride, and ammonia. The decomposing action of radium rays on the lecithin molecule has been observed by Schwara,4 Schaper,& and Werner.6 On the other hand, no s...

Radium-223 dichloride (radium-223) is an important therapeutic option for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases, and no visceral disease. The unique mechanism of action of this first-in-class alpha-emitting radiopharmaceutical underlies its favorable safety profile and low incidence of myelosuppression. In the pivotal phase 3 ALpharadin...

-Radium sorption efficiencies as a function of temperature, Ra concentration, and secondary mineral sorbate were determined in a 0.0! M NaC1 solution. Radium sorption on a characterized clinoptilolite, montmorillonite, nontronite, opal, silica gel, illite, kaolinite, and glauconite under comparable experimental conditions allowed determination of Ra sorption efficiency curves for each, through ...

The present study was undertaken with a view of determining in a general way the effects of intravenous administration of radium upon the circulation and respiration. The problem was suggested to us by Dr. William J. Gies, under whose guidance a number of researches, dealing with the more extensive question of the action of radium upon animal and vegetable cells, have recently been carried on i...

Radium-223 is a first-in-class alpha particle-emitting radiopharmaceutical approved for the treatment of bone metastatic castration-resistant prostate cancer. Radium-223 is administered intravenously with no requirement for complex shielding and specifically targets areas of bone metastasis. In a randomized placebo-controlled Phase III study, treatment with radium-223 was shown to improve overa...

background: everyone is exposed to radon because it is present everywhere with varying concentrations. radon and its progeny are well established as lung carcinogenic. materials and methods: track etch technique using lr-115 plastic track detectors has been used to measure the effective radium content and radon exhalation rates in soil samples collected from urban area of etah district of uttar...

OBJECTIVE This open-label, non-randomized, phase I study examined the pharmacokinetics (PK) and radiation dosimetry of a single dose of radium-223 in Japanese patients with castration-resistant prostate cancer (CRPC) and bone metastases. METHODS Six male Japanese patients (mean age 72.5 years, range 65-79 years) with histologically or cytologically confirmed stage IV adenocarcinoma of the pro...