BACKGROUND Astatine-211 (211At) is an alpha particle emitting halogen with almost optimal linear energy transfer for creating DNA double-strand breaks and is thus proposed for radionuclide therapy when bound to tumor-seeking agents. Unbound 211At accumulates in the thyroid gland, and the concept of basal radiation-induced biological effects in the thyroid tissue is, to a high degree, unknown an...

Targeted radionuclide therapy (TRT) is a promising technique for cancer therapy. However, in order to deliver the required dose to the tumor, minimize potential toxicity in normal organs, as well as monitor therapeutic effects, it is important to assess the individualized internal dosimetry based on patient-specific data. Advanced imaging techniques, especially radionuclide imaging, can be used...

The features of Hypertrophic pulmunary osteoarthropathy (HPOA) on radionuclide bone scintigraphy have been well described in case reports and small series of patients. The aim of this study was to investigate prospectively the prevalence and distribution of HPOA in a large series of patients with carcinoma of the lung. Two hundred and eleven patients aged 31-89 years (average age 66 years...

Radionuclide therapy is widely used as an effective modality in the management of bone pain. The main indication for this treatment is symptomatic bone metastases, confirmed by bone scintigraphy. We present a case of small cell lung cancer (SCLC) stage T4N2M1b, with a good metabolic response to systemic therapy and radiotherapy of the primary tumor and locoregional disease, which became metabol...

introduction evaluation of the delivered dose of externally wedged photon beams by external diode dosimeters during the treatment process requires the estimation of exit surface dose correction factors in various wedge angles and field sizes. materials and methods a system of absorbed dose evaluation, using p-type diode dosimeters placed on the exit surface of a phantom, was characterized for e...

For treatment of systemic malignancies, when external radiation therapy is not applicable, radionuclide therapy can be an alternative. In this form of therapy, radionuclides are administered to the patient, often in a form where the radionuclide is labelled to a molecule that plays the active part in the localization of the tumor. Since the aim is to impart lethal damage to tumor cells while ma...

Background: Hadron therapy for malignant tumor is becoming increasingly popular. There are many factors which effect on implementation of a proper treatment planning. The purpose of this work is to investigate the inhomogeneity effects as affecting factor on proton range, Full width at half maximum (FWHM) and 20% position of penumbra (P20) by MCNPX code. Materials and Methods: An inhomogeneous ...

background: high-velocity carbon ion beams represent the most advanced tool for radiotherapy of deep-seated tumors. currently, the superiority of carbon ion therapy is more prominent on lung cancer or hepatomas. materials and methods: the data for lateral straggling and projected range of monoenergetic 290 mev/u (3.48 gev) carbon ions in muscle tissue were obtained from the stopping and range o...