BACKGROUND Radicular pain is a common and debilitating clinical pain condition. To date, the mechanisms of radicular pain remain unclear, partly because of the lack of suitable preclinical models. The authors report a modified rat model of radicular pain that could mimic a subset of clinical radicular pain conditions induced by the soft tissue compression on dorsal root ganglion. METHODS A ra...

BACKGROUND Periapical lesions occur in response to chronic irritation in periapical tissue, generally resulting from an infected root canal. Specific etiological agents of induction, participating cell population and growth factors associated with maintenance and resolution of periapical lesions are incompletely understood. Among the cells found in periapical lesions, mast cells have been impli...

The aim of this study was to evaluate the immunohistochemical expression of molecules involved in osteoclastogenesis, including the receptor activator of nuclear factor kappa B (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) in odontogenic keratocysts (OKCs), which has been named as a keratocystic odontogenic tumour by the WHO, and compare their expression with radicular cysts and amelobl...

AIM Injury to the vascular supply to the cervical spinal cord can lead to the anterior spinal artery syndrome, which is often associated with transforaminal corticosteroid injections to the cervical foramina. The purpose of this cadaveric study was to examine the morphology of the cervical arteries and to emphasize their clinical importance. MATERIAL AND METHODS Five formalin-fixed human cada...

OBJECTIVE To use self-reported disability (Roland-Morris Disability Questionnaire [RMDQ]) to assess the criterion validity of straight leg raising (SLR) test and flexion range of motion (ROM) (fingertip-to-floor test) before and after stratification by sex and presence/absence of radicular pain. DESIGN Cross-sectional study. SETTING Outpatient physical therapy clinic. PARTICIPANTS Subject...

OBJECTIVE To assess the amount of maxillary and mandibular inter-radicular bone mass and determine the most reliable mini-screw placement sites. MATERIALS AND METHODS Retrospective Cone Beam Computed Tomography (CBCT) images of 40 Angle Class I subjects (20 females, 20 males, aged 16 to 32) were obtained. Measurements on the buccal (BI), medial (MI) and lingual (LI) sides of the inter-radicul...

BACKGROUND The aim of the study was to determine the usefulness of autologous serum in the treatment of patients with signs of radicular compression in the course of lumbar discopathy. The treatment was based on the use of autologous conditioned serum (ACS, Orthokine). MATERIAL AND METHODS A total of 15 patients with MRI-confirmed single-level nucleus pulposus herniation with signs of radicul...

In this study we present the efficacy of aspiration of disc material employing the Stryker Disc Dekompressor during percutaneous microdiscectomy for the treatment of chronic spinal and radicular pain due to contained lumber disc herniation and compare the short-term outcome in such patients with those who received lumber epidural injection. A total of 50 patients with chronic lumber discogenic ...