BACKGROUND Thoracic and cardiac irradiation increases the risk of pulmonary and cardiovascular disease. In addition, radiation, often in combination with chemotherapy, can cause treatment-related pneumonitis. Previously, we showed that the common marker for cardiac damage, troponin T, was not elevated by chemoradiation [Lung Cancer 62:351-355, 2008]. In this study, we explore whether dose-volum...

BACKGROUND Estimates of radiation-related second cancer risk among Hodgkin lymphoma survivors are largely based on radiation therapy (RT) fields and doses no longer in use, and these estimates do not account for differences in normal tissue dose among individual patients. This study gives individualized estimates for the risks of lung and female breast cancer expected with contemporary involved...

The challenges of lung cancer radiotherapy are intra/inter-fraction tumor/organ anatomy/motion changes and the need to spare surrounding critical structures. Evolving radiotherapy technologies, such as four-dimensional (4D) image-based motion management, daily on-board imaging and adaptive radiotherapy based on volumetric images over the course of radiotherapy, have enabled us to deliver higher...

BACKGROUND The optimal timing of chemoradiotherapy in limited-stage small-cell lung cancer (LS-SCLC) hasn't been established, although evidence from studies supported that patients can benefit from early radiation therapy. The purpose of this study was to quantify tumor shrinkage in response to induction chemotherapy (IC), evaluate the impact of tumor shrinkage on radiation dosimetric parameter...

Radiation induced lung injury has long been considered a treatment limiting factor for patients requiring thoracic radiation. This radiation induced lung injury happens early as well as late. Radiation induced lung injury can occur in two phases viz. early (<6 months) when it is called radiation pneumonitis and late (>6 months) when it is called radiation induced lung fibrosis. There are multip...

Bronchiolitis obliterans organizing pneumonia (BOOP) is defined histopathologically by the presence of a mass of granulation tissue in the bronchiolar lumen, alveolar ducts, and lung alveoli, along with varying degrees of interstitial infiltrate by mononuclear cells and, occasionally, by neutrophils.1,2 Radiographically, radiation-induced BOOP is characterized by pulmonary infiltrates that occu...

background: image-guided radiotherapy used multiple imaging during the radiation therapy course to improve the precision and accuracy of health care provider's treatment. objectives: this study aims to assess the safety, effectiveness and economic aspects of image-guided radiation therapy for decision-making about this technology in iran. methods: in this study, the most important medical datab...

Background: High-velocity carbon ion beams represent the most advanced tool for radiotherapy of deep-seated tumors. Currently, the superiority of carbon ion therapy is more prominent on lung cancer or hepatomas. Materials and Methods: The data for lateral straggling and projected range of monoenergetic 290 MeV/u (3.48 GeV) carbon ions in muscle tissue were obtained from the stopping and range o...