Bone marrow suppression due to ionizing radiation is a significant clinical problem in radiation therapy andfollowing non-medical radiation exposure. Currently, no small molecule agents that can enhance hematopoieticregeneration following radiation exposure are available. Here, we report the effective mitigation of acutehematopoietic radiation syndrome in mice by the synthetic trite...

background: the effects of aqueous extract of fadogia agrestis stem at the doses of 18, 36, and 72 mg/kg body weight on alloxan-induced toxicity was investigated in wistar rats. methods: in total, 35 rats of both sexes (132.80±7.22g) were randomized into five groups (a-e): animals in group a received 0.5 ml of distilled water orally on daily basis for 15 days while the alloxanized rats in group...

In this paper a numerical model to study the vibro-acoustic behavior of a laminated plate backed by a poroelastic foam layer is developed. Such approach consists on a coupled mitigation strategy aiming either mechanical vibration suppression or acoustic attenuation as well. The laminated plate model consists of fiber laminae with interleaved viscoelastic layers in standard constrained or integr...

Radiation therapy is one of the cornerstones of modern multidisciplinary cancer treatment. Normal tissue tolerance is critical as radiation-induced side effects may compromise organ function and quality of life. The importance of normal tissue research is reflected by the large number of scientific articles, which have been published between 2006 and 2010. The present study identified important...

The islands of the Caribbean are a particularly interesting geographical region to examine the dynamic relationship between past human communities and sudden environmental change. This chapter examines how past peoples, living on the islands in the Caribbean Sea, were vulnerable to a number of environmental threats. The focus of this chapter is the impact of floods, droughts, and wind shear cre...

Governments and donors are investing in climate compatible development in order to reduce climate and development vulnerabilities. However, the rate at which climate compatible development is being operationalised has outpaced academic enquiry into the concept. Interventions aiming to achieve climate compatible development "wins" (for development, mitigation, adaptation) can also create negativ...

Materials used in the exterior of buildings and in construction are routinely exposed to solar UV radiation. Especially in the case of wood and plastic building materials, the service life is determined by their weather-induced deterioration. Any further increase in ground-level solar UV radiation, UV-B radiation in particular, will therefore reduce the outdoor service life of these products. A...

Antibiotic and antifungal agents used in supportive care regimens for bone marrow transplantation recipients contribute to a significant dose-modifying effect of otherwise lethal total body irradiation. To determine whether drugs used in supportive care and other commonly used antibiotics such as tetracycline function as radiation protectors or damage mitigators in vitro, 13 drugs were tested f...