Pass, Jason M., Yuting Zheng, William B. Wead, Jun Zhang, Richard C. X. Li, Roberto Bolli, and Peipei Ping. PKCe activity induces dichotomous cardiac phenotypes and modulates PKCe-RACK interactions and RACK expression. Am J Physiol Heart Circ Physiol 280: H946–H955, 2001.—Receptors for activated C kinase (RACKs) have been shown to facilitate activation of protein kinase C (PKC). However, it is ...

In many data centers, server racks are highly underutilized. Rack slots are left empty to keep the sum of the server nameplate maximum power below the power provisioned to the rack, while the servers placed in the rack cannot make full use of available rack power. The root cause of this rack underutilization is that the server nameplate power is often much higher than can be reached in practice...

Rack-scale computers are dense clusters with hundreds of micro-servers per rack. Designed for data center workloads, they can have significant power, cost and performance benefits over current racks. The rack network can be distributed, with small packet switches embedded on each processor as part of a system-on-chip (SoC) design. Ingress/egress traffic is forwarded by SoCs that have direct upl...

The WD repeat-containing protein receptor for activated protein kinase C (RACK)-1 has been linked to a variety of signaling systems including protein kinase C, growth factors, and IFNs. In the IFN system, RACK-1 functions as an adaptor recruiting the transcription factor STAT1 to the receptor complex. However, RACK-1 should play a broader role in type I IFN signaling because mutation of the RAC...

Recent trends to pack data centers with more CPUs per rack have led to a scenario in which each individual rack may contain hundreds, or even thousands, of compute nodes using system-on-chip (SoC) architectures. At this increased scale, traditional rack-level star topologies with a top-ofrack (ToR) switch as the hub and servers as the leaves are no longer feasible in terms of monetary cost, phy...

Several interesting monitoring applications concern people entering a prescribed area, where they deposit an object in their possession, or collect an object deposited earlier. One example arises in the use of bicycle racks. We propose a novel method for associating each person who deposits an object with the person who later collects it. Our main contribution is to deal with ambiguity in the v...

Creating architecture for a complex telecommunication system is a difficult task and requires expertise of many different stakeholders. The software architecture design process relies on understanding the architecturally significant requirements (ASRs) for the system under design. This paper describes experiences in creating a new base station product line. A goal was to create a process to fac...

Migrating cells and growth cones extend lamellipodial and filopodial protrusions that are required for outgrowth and guidance. The mechanisms of cytoskeletal regulation that underlie cell and growth cone migration are of much interest to developmental biologists. Previous studies have shown that the Arp2/3 complex and UNC-115/abLIM act redundantly to mediate growth cone lamellipodia and filopod...

Aging is associated with remodeling of the immune system, contributing to increased incidence of infections, autoimmune diseases, and cancer among the elderly. Alterations in several signal transduction pathways have been reported to play an important role in immunosenescence. We show that peripheral blood leukocytes obtained from old donors (> or =65 years) have a significantly reduced express...

In conventional power plants trash-racks are provided at the intakes to protect the turbines. In pumped storage plants, the draft tube or tailrace must also have trash-racks to protect the units while pumping. Because the loads believed to cause many failures of trash-racks are dynamic in nature, it is important to understand the dynamic characteristics of trash-rack structures in general and a...