Substitution of the C-terminal leucine heptad repeat region of the normally tetrameric lactose repressor by the leucine heptad repeat dimerization domain of GCN4 protein resulted in cell extracts containing protein, designated R3, which behaved as a dimer based on gel retardation analysis of DNA binding (Alberti, S., Oehler, S., von Wilcken-Bergmann, B., and Müller-Hill, B. (1993) EMBO J. 12, 3...

Bone marrow cells were isolated from the humeri of C57BL/6 mice after a 13-day flight on the space shuttle Space Transportation System (STS)-118 to determine how spaceflight affects differentiation of cells in the granulocytic lineage. We used flow cytometry to assess the expression of molecules that define the maturation/activation state of cells in the granulocytic lineage on three bone marro...

We prove a dispersive estimate for the evolution of Schrödinger operators H = −∆ + V (x) in R3. The potential is allowed to be a complex-valued function belonging to Lp(R3) ∩ Lq(R3), p < 3 2 < q, so that H need not be self-adjoint or even symmetric. Some additional spectral conditions are imposed, namely that no resonances of H exist anywhere within the interval [0,∞) and that eigenfunctions at...

We examined the function of GFP-IP(3)R3 (green fluorescent protein-tagged inositol 1,4,5-trisphosphate receptor type 3) in Ca(2+) release and entry using a mutant DT40 cell line (IP(3)R-KO) in which all three IP(3)R genes had been disrupted. GFP-IP(3)R3 fluorescence largely overlapped with the distribution of endoplasmic reticulum, whereas a portion of GFP-IP(3)R3 apparently co-localized with t...

The famous Erdös-Mordell inequality in geometric inequalities states the following: Let P be an interior point of a triangle ABC. Let R1, R2, R3 be the distances from P to the vertices A,B,C, and let r1, r2, r3 be the distance from P to the sides BC,CA,AB, respectively. Then R1 +R2 +R3 ≥ 2(r1 + r2 + r3), (1.1) with equality if and only if △ABC is equilateral and P is its center. This equality w...

The transcription factor genes Hoxa1 and Krox-20 have been shown to play important roles in vertebrate hindbrain segmentation. In this report, we present evidence for novel functions of these genes which co-operate in specifying cellular identity in rhombomere (r) 3. Although Hoxa1 has not been observed to be expressed rostrally to the prospective r3/r4 boundary, its inactivation results in (i)...

We study a relationship between arc presentations of links in R3 and Legendrian links in R3 with the standard tight contact structure. We determine the arc indices of torus knots.