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Ample data exist contending that wild-type p53 and E2F-1 cooperate to mediate apoptosis, that E2F-1-mediated apoptosis is p53 dependent in some situations, and that E2F-1 can induce accumulation of p53 in manunalian cells. These data support the investigation of the biological consequences of combined wild-typep53 and E2F-1 overexpression in human squamous cell carcinoma of the head and neck (S...

STUDY QUESTION Are lifestyle factors (smoking, BMI, alcohol use and oral contraceptive pill use) associated with the human ovarian reserve as determined by the total ovarian non-growing follicle number? SUMMARY ANSWER Light to moderate alcohol use was significantly associated with greater ovarian non-growing follicle (NGF) count, whereas other lifestyle factors were not significantly related....

Efficient syntactic and semantic parsing for ambiguous context-free languages are generally characterized as complex, specialized, highly formal algorithms. In fact, they are readily constructed from straightforward recursive Iransition networks (RTNs). In this paper, we introduce LR-RTNs, and then computationally motivate a uniform progression from basic LR parsing, to Earley's (chart) parsing...

No. lee650 Oxidative Mapping of Alzheimer's Disease Amyloid Fibrils J. Lee, K. Iwata, S. Oh, M. Lachenmann and G. Hernandez (Boston U.) Beamline(s): X28C Introduction: Alzheimer’s disease amyloid fibrils are conglomerates of a large number of Abeta peptide molecules (40-43 residues). Because of their size, and rapid formation, conventional NMR and X-ray structural methods cannot be applied to t...

T of parts of the MHC has grown substantially within the last year. HE MAJOR HISTOCOMPATIBILITY complex (MHC) is an extended cluster of genes that are remarkable for the number and importance of the immunological functions The MHC is of major biomedical interest because of its contribution to transplant rejection and to variation between they encode. Historically, interest in the MHC emanated f...

SINCE THE ADVENT of modern embryonic stem cell technology, mice with targeted gene deletion have come into use as model organisms to study the mechanisms of protection from ischemic injury. Heme oxygenases (HO) have gained considerable interest because of their potential neuroprotective effect (1, 8). HO converts pro-oxidant heme to biliverdin and carbon monoxide (CO), which may act as a neurot...

Despite an intriguing cell biology and the suggestion of a role in pathophysiological responses, the mechanism of action of such lipid phosphoric acid mediators as lysophosphatidic acid (LPA) remains obscure, in part because of an underdeveloped medicinal chemistry. We report now the agonist activity of a synthetic phospholipid in which the glycerol backbone of LPA is replaced by L-serine. Like...

Purpose: IFN-based therapy has been shown to be active in the treatment of squamous cell carcinoma (SCC) of the skin, the most aggressive form of non-melanoma skin cancer. Based largely on this activity, we began programmatically examining the expression of IFN-stimulated gene factor 3 (ISGF-3) proteins (signal transducers and activators of transcription 1 / , signal transducers and activators ...