Introduction: The effective rate of decay of transverse magnetization, R2* = 1/T2*, is sensitive to B0 distortions at a mesoscopic scale (1). It is thus highly correlated to tissue concentrations of non-heme iron (2) and myelinated axons (3), especially at high and ultra-high field strengths (2-4). R2* is commonly measured using long-TR multi-slice gradient echo sequences. This approach implies...

One can prove the following four propositions: (1) For all points p, q of E2 T and for every subset P of E2 T such that P is an arc from p to q holds P is compact. (2) For every real number r holds 0 ¬ r and r ¬ 1 iff r ∈ the carrier of I. (3) For all points p1, p2 of E 2 T and for all real numbers r1, r2 such that (1 − r1) · p1 + r1 · p2 = (1 − r2) · p1 + r2 · p2 holds r1 = r2 or p1 = p2. (4) ...

ID: 6000 Title: MRI Relaxometry BMD Measurements using Conventional Phase Symmetrized Rapid Increased Flip Spin Echo and Standard Gradient Echo and its correlation with DXA Purpose: Recently, several special MRI protocols have been developed for BMD measurements for deriving R2(=1/T2), R2*(=1/T2*) and R2'(=R2*-R2) applied in several cross sectional studies. But, due to high slew rate gradients ...

The small subunit of Escherichia coli ribonucleotide reductase (R2) is a homodimeric (betabeta) protein, in which each beta-peptide contains a diiron cluster composed of two inequivalent iron sites. R2 is capable of reductively activating O(2) to produce a stable tyrosine radical (Y122*), which is essential for production of deoxyribonucleotides on the larger R1 subunit. In this work, the param...

Introduction pH sensing has a pivotal role in diagnosis, e.g. tumors or inflammation sites have a lower pH as compared to pH 7.4 of normal tissues. This acidic environment, e.g. 6.5 or lower, has been used for an effective delivery of therapeutic agents, especially using liposomes. Sensitive probes or systems that can detect this change in vivo are necessary for disease diagnosis. Liposomes act...

PURPOSE To elucidate vascular endothelial growth factor (VEGF)-mediated pathogenesis of fibrovascular proliferation in diabetic retinopathy. METHODS Fibrovascular tissues were obtained at vitrectomy from 22 cases with proliferative diabetic retinopathy. The half-divided tissues were processed for reverse transcription-polymerase chain reaction (RT-PCR) analysis to examine the expression of VE...

We report on the separate PCR cloning and subsequent expression and purification of the large (R1) and small (R2) subunits from equine herpes virus type 4 (EHV-4) ribonucleotide reductase. The EHV-4 R1 and R2 subunits reconstituted an active enzyme and their abilities to complement the R1 and R2 subunits from the closely related herpes simplex virus 1 (HSV-1) ribonucleotide reductase, with the ...

The use of small angle neutron scattering, SANS, neutron reflectivity, NR, and surface tension to study the mixing properties of the biosurfactant rhamnolipid with a conventional anionic surfactant, sodium dodecyl 6-benzene sulfonate, LAS, is reported. The monorhamnose rhamnolipid, R1, mixes close to ideally with LAS at the air-water interface, whereas for mixtures of LAS with the dirhamnose rh...