Inositol 1,4,5-trisphosphate receptors (InsP(3)R) play a key role in intracellular calcium (Ca(2+)) signaling. Three InsP(3)R isoforms are expressed in mammals. Type 1 InsP(3)R (InsP(3)R1) is a predominant neuronal isoform. Neuronal InsP(3)R1 is one of the major substrates of protein kinase A (PKA) phosphorylation. In our previous study (Tang, T. S., Tu, H., Wang, Z., and Bezprozvanny, I. (2003...

The first two vocal tract resonances (R1 and R2) of 22 classically trained sopranos, altos, tenors, and baritones were measured while they sang four different vowels over their normal pitch range. The resonances of the tract and the harmonics of the voice were measured simultaneously by injecting a broadband acoustic current into the tract at their mouth. Sopranos were found to tune R1 close to...

Availability of an innocuous and repeatable technique for monitoring tumor oxygenation throughout therapeutic course should be a key factor for adaptative therapeutic strategies. We previously qualified lipids R1 as a marker of oxygen level on experimental tumor models. The objectives of the present study were to assess the applicability of measuring lipids R1 in primary central nervous system ...

In somatic hybrids between fibroblast microcells and rat hepatoma cells, tissue-specific extinguisher 1 (TSE1), localized to mouse chromosome 11, extinguishes the expression of tyrosine aminotransferase and phospho(enol)pyruvate carboxykinase. Recently, it was demonstrated that TSE1 corresponds to R1 alpha, a regulatory subunit of protein kinase A. Here, we have analyzed whether R1 alpha could ...

i=1 H(ri); (5) HΨ(r1, r2, · · · ) = EΨ(r1, r2, · · · ). (6) (Note: For simplicity, unless necessary, we often write r as r.) Since there is no interaction between particles, the Schrodinger equation is separable. Assume Ψ(r1, r2, · · · , rN ) = φ(r1)φ(r2) · · ·φ(rN ), (7) then Hφαi(ri) = εαiφαi(ri), i = 1, 2, · · ·N. (8) Manybody eigenstate is a product of 1-particle states, Ψα1,α2,···(r1, r2, ...

A specific polyclonal Ab against the N-terminal domain of corticotropin-releasing factor (CRF) receptor, type 1 (CRF-R1), was employed to an immunohistochemical analysis of the spleen from naive mice and mice exposed to an immune challenge. Cell types stained with anti-CRF-R1 Ab were identified by their nuclear shapes and colocalization with the cell type-specific markers ER-MP58, ER-MP20, Moma...

Advanced glycation endproducts (AGE) contribute to kidney disease due to diabetes or aging by means of mesangial cell (MC) receptors, such as the receptor for AGE (RAGE), which promote oxidant-stress-dependent NF-kappaB activation and inflammatory gene expression. MC also express scavenger receptors SR-I and SR-II and AGE receptors 1, 2, and 3 (AGE-R1, -R2, and -R3), some of which are linked to...

Antimutagenic substances were purified from a culture supernatant of Lactobacillus plantarum KLAB21 cells isolated from kimchi, a Korean traditional fermented vegetable, and their characteristics were investigated. The antimutagenic substances were separated into two fractions by DEAE-cellulose ion-exchange column chromatography, which were designated the R1 and R2 fractions. The R1 fraction wa...

Streptococcus pneumoniae is a microorganism that frequently causes serious infections in children, the elderly, and immunocompromised patients. We studied whether the specific intracellular adhesion molecule-grabbing nonintegrin R1 (Sign-R1) receptor, involved in the uptake of capsular polysaccharides (caps-PS) by antigen-presenting cells, is necessary for the antibody response to pneumococcal ...

Let R = ⊕ g∈GRg be a G-graded ring. It is well known (see e.g. [D], [M1], [N], [NRV], [NV]) that in the study of the connections that may be established between the categories R-gr of graded R-modules and R1-mod (1 is the unit element of G), an important role is played by the following system of functors : (−)1 : R-gr → R1-mod given by M 7→ M1, where M = ⊕ g∈GMg is a graded left R-module, the i...