Quinoline and its derivatives represent an important class of nitrogen containing heterocycles because they are useful intermediates in organic synthesis biological activities such as antiasthmatic, anti-inflammatory, anti- cancer, antimalarial activity. A quinoline eight compounds was successfully synthesized characterized by FT-IR, 1H NMR, 13C NMR mass spectral analysis. Therefore, the new wi...

ligands derived from 8-quinoline, 6-quinoline, 1 -isoquinoline, and 5-isoquinoline were synthesized. these compounds have been used as ligands for complexation of transition metals, such as copper(ii) and nickel(ii). according to the spectrosocopic data, copper(ii) cation forms (i: 1) and (i:2) complexes with 2-(8-quinoly1)-l,l,3,3- tetramethylguanidine and 2- (i '-isoquinoly1)- 1,1,3,3-te...

PURPOSE. A new series of substituted quinoline-2(1H)-one and 1,2,4triazolo[4,3-a]-quinoline derivatives were designed and synthesized to meet the structural requirements essential for anticonvulsant properties. METHODS. 4-substituted-phenyl3,4-dihydro-2(1H)-quinolines, 5-substitutedphenyl-4,5-dihydro-1,2,4-triazolo[4,3a]quinolines and 5-substituted-phenyl-4,5-dihydro-1,2,4triazolo-[4,3-a]quinol...

Quinoline was used to probe the steric and electronic contributions to rates of aromatic oxidation of nitrogen-containing, multiring substrates by cytochrome P450 (P450) enzymes. The regioselectivity of the P450 oxidation of quinoline was determined experimentally by identifying and measuring the ratios of metabolites. The laboratory results were compared with those obtained computationally by ...

Quinoline-3-carboxamides are an essential class of drug-like small molecules that known to inhibit the phosphatidylinositol 3-kinase-related kinases (PIKK) family kinases. The quinoline nitrogen is shown bind hinge region kinases, making them competitive inhibitors adenosine triphosphate (ATP). We have previously designed and synthesized quinoline-3-carboxamides as potential ataxia telangiectas...

Abstract In response to the malaria parasite’s resistance towards quinoline-based antimalarial drugs, we have employed quinoline-containing compounds in combination with dihydropyrimidinone (DHPM) analogues as reversal agents (RAs) and investigated their activities based on DHPM’s abilities. The present study click chemistry link DHPM quinoline which offered several synthetic advantages over pr...

The title compound, C(10)H(11)N(4) (+)·Cl(-), has been synthesized by the reaction of 8-amino-quinoline and cyanamide. The dihedral angle between the plane of the guanidine group and the quinoline ring system is 68.64 (13)°. The crystal structure is stabilized by inter-molecular N-H⋯Cl hydrogen bonds.

Susceptibility to quinoline antimalarial intoxication may reflect individual genetic and drug-induced variation in neuropharmacokinetics. In this report, we describe a case of chloroquine intoxication that appeared to be prolonged by subsequent use of multiple psychotropic medications. This case highlights important new considerations for the management of quinoline antimalarial intoxication.

FeCl3- and FeBr3-mediated tandem carboarylation/cyclization of propargylanilines with diethyl benzaldehyde acetals furnished the tetracyclic core of indeno[2,1-c]quinolines. 5-Tosyl-6,7-dihydro-5H-indeno[2,1-c]quinoline and 7H-indeno[2,1-c]quinoline derivatives were obtained in good to excellent yields, respectively, by tuning the FeX3 loadings and/or reaction temperatures.

The title compound, C(13)H(11)N(3)O, a potential chemotherapeutic agent, contains a essential planar [maximum deviation = 0.0144 (14) Å] quinoline moiety. The quinoline ring system and the five-membered heterocycle form a dihedral angle of 7.81 (6)°. In the crystal, inter-molecular non-classical C-H⋯N hydrogen bonding is present.