نتایج جستجو برای: quinazolinone
تعداد نتایج: 353 فیلتر نتایج به سال:
Crosstalk between apoptosis and autophagy is budding as one of the novel strategies in the cancer therapeutics. The present study tinted toward the interdependence of autophagy and apoptosis induce by a novel quinazolinone derivative 2,3-dihydro-2-(quinoline-5-yl) quinazolin-4(1H)-one structure [DQQ] in human leukemia MOLT-4 cells. DQQ induces cytochrome c arbitrated apoptosis and autophagy in ...
The hitherto unknown bis[quinazolin-4-one-2-yl]-m-phenylene (2d), and its 3-N-substituted derivatives were prepared from the corresponding bis[3,1-benzoxazin-4-one-2-yl]-m-phenylene (1) as precursor. The quinazolinone derivative 2d was converted into bis[quinazolin-4-thioxo-2-yl]-m-phenylene (3) via different routes, bis[4-chloroquinazolin-2-yl]-m-phenylene (8) and bis[4-hydrazinoquinazolin-2-y...
Abbreviations: Aβ: Amyloid-β Peptide; AD: Alzheimer’s Disease; APP: Amyloid Precursor Protein; ATG: Autophagy-related Protein; Drp1p: Dynamin-Related Protein 1; ER: Endoplasmic Reticulum; ERK: Extracellular signal–Regulated Kinase; HIF: Hypoxia-Inducible Factor; MAM: Mitochondrion-Associated Endoplasmic Reticulum Membrane; MAP: Microtubule Associated Protein; MAPK: MitogenActivated Protein Kina...
A proposed structure for schizocommunin (Z)-1(hydroxy) and its geometric isomer (E)-1(hydroxy), which exist in a keto form, has been synthesized. However, the spectroscopic data of (Z)-1(keto) and (E)-1(keto) were not consistent with those reported for natural schizocommunin. After reinvestigating the spectral data for natural schizocommunin, we synthesized the quinazolinone derivative (Z)-2 as...
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