To assess the effects of pharmacological interruption of the renin-angiotensin system on the fibrinolysis, tissue plasminogen activator antigen (t-PA), plasminogen activator inhibitor-1 antigens (PAI-1) and neurohormones, such as plasma renin activity, norepinephrine, angiotensin II (AII) and IV (AIV) concentrations, were measured in 60 hypertensives. Among them, 48 patients were divided into t...

from a creatine kinase-based enzyme rise to a troponin-based rise. Use of beta-blockers in patients with left ventricular (LV) impairment is also strongly supported by numerous controlled trials, and these patients should certainly receive beta-blockers post-CABG. We agree that use of beta-blockers in patients without prior MI (ST-segment or non–ST-segment elevation) or LV impairment is more de...

Low density lipoprotein (LDL) was incubated with 20 microM of the angiotensin converting enzyme (ACE) inhibitors captopril, fosinopril and quinapril or ethanol. Oxidation of LDL was initiated by addition of CuSO4 and monitored for production of conjugated dienes, thiobarbituric acid reactive substances (TBARS) and lipid peroxides. The inhibition of production of conjugated dienes was expressed ...

Background: Angiotensin converting enzyme (ACE) inhibitor toxicity is infrequently reported and seldom produces significant clinical effects. Only 15 previous cases of intentional ACE inhibitor overdoses among adults have been published. The most commonly observed clinical effect is hypotension, which is typically transitory and responsive to supportive measures and intravenous hydration. An ad...

Objective of the present study was to investigate the elimination kinetics of quinaprilat and perindoprilat, the active metabolites of angiotensin-converting enzyme (ACE) inhibitors quinapril and perindopril, in hypertensive patients with renal failure under haemodialysis to evaluate the appropriate duration of off-dose of these drugs before starting of low-density lipoprotein (LDL) apheresis. ...

The Supreme Court recently denied certiorari to review the Federal Circuit’s ruling in Apotex v. Pfizer (S. Ct. 906-1006, October 16, 2006). The ruling was predictable. Pfizer had mooted the case by providing a covenant not to sue Apotex on its Quinapril patent. But the underlying legal issue – subject matter jurisdiction in declaratory judgment cases – is currently pending before the Supreme C...

Quinapril hydrochloride and hydrochlorothiazide were simultaneously determined by HPTLC in pharmaceutical formulations. The drugs were separated on silica gel 60 F(254) plates using suitable combination of solvents as mobile phase. The validation parameters, tested in accordance with the requirements of ICH guidelines, prove the suitability of methods.

This study examined the role of the renin-angiotensin-aldosterone system (RAAS) in mediating cardiovascular and renal damage in spontaneously hypertensive rats (SHR) given salt excess. Since the circulating RAAS is inhibited in this model, it permits examination of the role of local tissue RAASs in mediating this injury. To this end, male 8-wk SHR were divided into 7 groups. The control group (...

A glomerular permeability defect occurs early in the course of type 1 diabetes and precedes the onset of microalbuminuria and renal morphological changes. Recently, ACE inhibitors have been shown to prevent loss of glomerular membrane permselective function, but the mechanism of this nephroprotective effect is still being debated. The objective of the present study was to evaluate the effects o...