Here we report the case of a 30-year-old woman with relapsed acute myeloid leukemia (AML) who was treated with all-trans retinoic acid (ATRA) as part of investigational therapy (NCT02273102). The patient died from rapid disease progression following eight days of continuous treatment with ATRA. Karyotype analysis and RNA-Seq revealed the presence of a novel t(4;15)(q31;q22) reciprocal transloca...

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma and exhibits aggressive and heterogeneous clinical behavior. To genetically characterize DLBCL, we established our own array-based comparative genomic hybridization and analyzed a total of 70 cases [26 CD-positive (CD5+) DLBCL and 44 CD5-negative (CD5-) DLBCL cases]. Regions of genomic aberrations observed i...

This paper considers two methods for pricing assets and examines the relations between them. The +rst method is based on the principle of no-arbitrage, which asserts that introduction of the new asset should not create an arbitrage in a market that was before arbitrage free. This condition is satis+ed by prices for the new asset between speci+c lower and upper limits, determined as the values o...

We develop a model to study the implications of a legal environment on the organization of software production. We show that contract enforcement a®ects the organizational mode (i.e., in-house versus outsourcing) of customized software development while copyright protection determines the introduction of package software. When copyright protection is weak, only customized software will be devel...

Standard economic analysis holds that labor market rigidities are harmful for job creation and typically increase unemployment. But many orthodox reforms of the labor market have proved di±cult to implement because of political opposition. For these reasons it is important to explain why we observe such regulations. In this paper I outline a theory of how they may arise and why they ̄t together...

Context. Observations with the Hinode spectro-polarimeter have revealed strong horizontal internetwork magnetic fields in the quiet solar photosphere. Aims. We aim at interpreting the observations by means of results from numerical simulations. Methods. Radiative MHD simulations of dynamo action by near-surface convection are analyzed with respect to the relation between vertical and horizontal...