Five series of tetrahydrobenzothieno[2,3-d]pyrimidine and tetrahydrobenzothienotriazolopyrimidine derivatives have been synthesized namely: 4-(substituted amino)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidines 4a–d, 4-substituted (methylidenehydrazino)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidines 6a–c, 4-(3,5-disubstituted pyrazol-1-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine...

The arylidienes of spiro thiazolidines (5) containing α,β-unsaturated function have been used as component of Micheal addition with equimolar amount of 2-aminopyridine (6a) to give novel spiro [indole-3,2′-pyrido[1,2-a]thiazolo[5,4-e]pyrimidines] (7) in a single step under microwaves in presence of montmorillonite KSF as solid support. The new improved synthetic method for spiro [indole-3, 2′-t...

The incorporation in vivo of compounds labeled with N15 or Cl4 into the purines and pyrimidines of nucleic acid has been repeatedly demonstrated (e.g. (l-3)). W e wish to report observations on the incorporation of radioactive erotic acid in vitro into the pyrimidines of the nucleic acid of rat liver slices. It is believed that this procedure will readily permit the study of precursors of nucle...

silica-bonded n-propyldiethylenetriamine sulfamic acid (spdtsa) is employed as a recyclable heterogeneous solid acid catalyst for the synthesis of benzopyrano[2,3-d]pyrimidines  through one-pot condensation reaction of salicylaldehydes, malononitrile and secondary amines  at room temperature under solvent-free conditions. spdtsa showed much the same efficiency when used in consecutive reaction ...

Oxazolo[5,4-d]pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives. In particular, 5-aminooxazolo[5,4-d]pyrimidine-7(6H)-ones (9-oxa-guanines) have been shown to inhibit ricin. The preparation of a series of 2-substituted 5-aminooxazolo[5,4-d]pyrimidin-...

The chemical changes occurring during embryonic development have been studied by several workers (l-3). In the hen’s egg there is very little nucleic acid present, whereas a considerable synthesis of both desoxypentose nucleic acid (DNA) and ribose nucleic acid (RNA) occurs in the embryo (4-6). Recently, methods for the determination of purines and pyrimidines in small amounts of tissue have be...

The metabolism of exogenous uridine, uridine 5’-monophosphate, and uracil by rat liver slices was studied using in vitro superfusion systems. Mixtures of 3Hand 14Clabeled uridine, uridine 5’-monophosphate, uracil, and erotic acid were superfused at a constant rate until an isotopic steady state was achieved. Isotopic ratios and concentrations of labeled pyrimidines were measured in tissue and p...