A carboxylated adenosine analog (C-Ado−) has been synthesized and probed via time-resolved photoelectron spectroscopy in order to induce intra-molecular charge transfer from the carboxylic acid moiety nucleobase. Intra-molecular can be exploited as starting point probe low-energy electron (LEE) damage DNA its derivatives. Time-dependent density functional theory (TD-DFT) calculations at B3LYP-6...

Nucleobase interactions play a fundamental role in biological functions, including transcription and translation. Natural nucleic acids like DNA are also widely implemented in material realm such as DNA guided self-assembly of nanomaterials. Inspired by that, polymer chemists have contributed phenomenal endeavors to mimic both the structures and functions of natural nucleic acids in synthetic p...

there has been special interest in the chemistry of quinolone and pyrimidine derivatives due to their diverse biological activities such as anticonvulsant, anti-malarial agents, antibacterial, antiviral, cytostatic, antithelemintic, antigenotoxic, anti-cancer agents. these compounds are also used as targeting delayed-type hypersensivity and anti-convulsant agents. as a part of our research work...

Effects are discussed of the anisotropic DNA environment on nitrosative guanine deamination based on results of an ab initio study of the aggregate 3 formed by guaninediazonium ion 1 and cytosine 2. Within 3, the protonation of 2 by 1 is fast and exothermic and forms 6, an aggregate between betaine 4 (2-diazonium-9H-purin-6-olate) and cytosinium ion 5. Electronic structure analysis of 4 shows t...

Near threshold photoexcitation of iodide–thiouracil clusters explores the coupling nucleobase centred excitations onto electron detachment spectrum.

Challenges and opportunities in supramolecular self-assembly of synthetic nucleobase-containing copolymers.

Hydrogen bonds (H-bonds) formed between nucleobases play an important role in the construction of various nucleic acid structures. The H-donor and H-acceptor pattern of a nucleobase is responsible for selective and correct base pair formation. Herein, we describe an 8-thioadenine nucleobase analogue and an 8-thiohypoxanthine nucleobase analogue with a photolabile 6-nitroveratryl (NV) group on t...

As part of an evolution-function analysis, two nucleobase cation symporter 1 (NCS1) from the moss Physcomitrella patens (PpNCS1A and PpNCS1B) are examined--the first such analysis of nucleobase transporters from early land plants. The solute specificity profiles for the moss NCS1 were determined through heterologous expression, growth and radiolabeled uptake experiments in NCS1-deficient Saccha...

Of all properties of metal nucleobase complexes, formation of multinuclear species appears to be an outstanding feature. After a brief introduction into well known polymeric metal nucleobase complexes, three aspects recently Studied in our laboratory will be dealt with in more detail: (i) Heteronuclear complexes derived from trans-[(amine)(2)Pt(1-MeC)(2)](2+) (1-MeC=1-methylcytosine). They form...