It has been shown that, when tryptophan is administered to rats, an increased excretion of niacin and some of its derivatives occurs (l-4). Isotope studies by Heidelberger et al. (5, 6) have given further evidence that niacin can be derived from tryptophan in the animal body. Vitamin Bs has been implicated in this transformation, since in a pyridoxine deficiency the excretion of an abnormal met...

Context: Vitamin B6, which is known as pyridoxine, used a nutritional supplement for many therapeutic purposes in medical centers. Women's health important because they are assumed the guarantors of societies. Breast pain common complaint women reproductive age and one most reasons women’s referral to The present study reviewed impact vitamin B6 on breast pain. Evidence Acquisition: In order ga...

In studies with pyridoxine and other B(6) compounds in blood, the active forms pyridoxal and pyridoxal phosphate were measured by differential assays using Lactobacillus casei. Red cell uptake of tritiated pyridoxine was also measured. A new metabolic pathway for conversion of pyridoxine to active forms was demonstrated in red cells. In vivo studies in normal subjects suggested that pyridoxine ...

Eight children with pyridoxine-dependent seizures (PDS) were seen over a period of 10 years. Of those children, 6 are on regular follow-up. Four of the children were seen in one family. All the patients presented with refractory seizures, mainly neonatal status epilepticus. Though PDS is a rare condition, it must be considered in all cases with refractory seizures, particularly in children youn...

1. Evidence is presented for the presence of pyridoxine phosphate oxidase in aqueous extracts of Escherichia coli. Some comparison is made with pyridoxamine phosphate oxidase. 2. Isoniazid and iproniazid were found to combine with pyridoxal phosphate, but isoniazid did not combine with either pyridoxamine phosphate or pyridoxine phosphate. Both oxidase activities were somewhat inhibited by benz...

Complications of long-term linezolid administration include anemia and thrombocytopenia. A recent report has suggested that pyridoxine may prevent myelosuppression. Pyridoxine was administered to 24 patients with bone infections who were being treated with linezolid. Thrombocytopenia occurred in 11 patients (45.8%), and anemia occurred in 6 (25%). We concluded that treatment wtih pyridoxine is ...

Rifampicin-resistant tuberculosis (RR-TB) is a global public health problem caused by mycobacterium resistant to Rifampicin. Drug-induced peripheral neuropathy and neurotoxicity are well-known adverse effects of treatment regimens that cause significant morbidity. Pyridoxine often added for the prevention and/or these side effects. The basis effectiveness this practice unclear. We conducted sys...

AIM The long-term outcome of the Dutch pyridoxine-dependent epilepsy cohort and correlations between patient characteristics and follow-up data were retrospectively studied. METHOD Fourteen patients recruited from a national reference laboratory were included (four males, 10 females, from 11 families; median age at assessment 6y; range 2y 6mo-16y). The following data were retrieved: sex; age ...

The concentrations of serotonin in various brain areas were significantly decreased in the pyridoxine-deficient young rat. There was no change in the concentration of dopamine. Both Bmax and Kd of [3H]serotonin binding to membrane preparations from cerebral cortex were increased in deficiency and were restored to normal upon pyridoxine supplementation. There was no change in [3H]spiroperidol bi...

The incidence of granulocytopenia in a series of 5,745 cases of thiouracil administration has been reported to be 2.5%o,8 and clinical studies have suggested that pyridoxine in large doses is of value in restoring the blood picture to normal.' The present experiments were devised to determine (a) if granulocytopenia could be induced in pyridoxine-deficient and in adequately fed mice by the use ...