Abstract: The effective methods have been developed for the preparation under mild conditions of novel pyridazine derivatives from the easily accessible starting materials. All the synthesized compounds were fully characterized. Various pyridazinone compounds were synthesized and tested for their antibacterial against various Gram positive and Gram negative bacterial strains such as Staphylococ...

[14C]7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine ([14C]-TPA023; 99 microCi/dose) was administered to five young, healthy, fasted male subjects as a single oral dose (3.0 mg) in solution (propylene glycol/water, 10:90 v/v). The parent compound was rapidly absorbed (plasma Tmax approximately 2 h), exhibited an apparent terminal...

The asymmetric unit of the title compound, C(16)H(20)N(4), contains two half-mol-ecules, which are completed by crystallographic inversion symmetry. The pyridazine rings are conjugated and the cyclo-hexane rings adopt envelope conformations.

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in 13 C nu...

The title compound, C(12)H(12)N(4), was synthesized by the reaction of hydrazine hydrate and 9-methyl-3,4,6,7-tetra-hydro-2H-xanthene-1,8(5H,9H)-dione in ethanol. In the crystal, the mol-ecule lies across an inversion centre. The pyridazine rings are coplanar and the C(6) rings adopt envelope conformations.

An effective method has been developed for the preparation under mild conditions of novel pyridazine derivatives from the easily accessible starting materials mucochloric acid and benzene. All the synthesized compounds were fully characterized and some of them displayed good antifungal activities against G. zeae, F. oxysporum and C. mandshurica in preliminary antifungal activity tests.

The title compound, [Co(C5H3N2O2)2(H2O)2]·2H2O, contains a Co(II) ion on an inversion center, exhibiting an octa-hedral coordination geometry. The equatorial plane is formed by two trans-related N,O-bidentate pyridazine-3-carboxyl-ate ligands and the axial positions are occupied by two water mol-ecules. The Co(II) complex mol-ecules are stacked in a column along the a-axis direction by an O-H⋯N...

Several new pryrazolo-pyridazine derivatives (4a-h) were synthesized through multi-step synthesis and evaluated for their antimicrobial activities. In the first step, 6-phenyl-2,3,4,5-tetrahydropyridazin-3-one (2) was prepared by reacting 4-(4-chlorophenyl)-4-oxobutanoic acid (1) with hydrazine hydrate. Then, aryl-aldehydes were reacted with 2 to furnish pyridazinone derivatives (3a-g). Finally...

For the purpose of discovering novel type-II inhibitors of vascular endothelial growth factor receptor 2 (VEGFR2) kinase, we designed and synthesized 5,6-fused heterocyclic compounds bearing a anilide group. A co-crystal structure analysis of imidazo[1,2-b]pyridazine derivative 2 with VEGFR2 revealed that the N1-nitrogen of imidazo[1,2-b]pyridazine core interacts with the backbone NH group of C...