PURPOSE 5-iodo-2-pyrimidinone-2'-deoxyribose (IPdR) is a pyrimidinone nucleoside prodrug of 5-iododeoxyuridine (IUdR) under investigation as an orally administered radiosensitizer. We previously reported that the mismatch repair (MMR) proteins (both hMSH2 and hMLH1) impact on the extent (percentage) of IUdR-DNA incorporation and subsequent in vitro IUdR-mediated radiosensitization in human tumo...

Peptide nucleic acids containing 2-pyrimidinone (P) and 3-oxo-2,3-dihydropyridazine (E) heterocycles recognized C-G and U-A inversions in a polypurine tract of double helical RNA with high affinity and sequence selectivity at pH 6.25. E-modified PNA bound strongly to bacterial A-site RNA, while no binding was observed to the human A-site RNA.

In the title compound, C(20)H(15)N(3)O(2)·C(18)H(15)OP, the pyrimidinone heterocycle and the fused phenyl ring are inclined at 1.92 (7)°. Only the hy-droxy group is involved in hydrogen bonding, whereas the amino group is shielded from potential acceptors.

A new series of thienothiadiazolopyrimidinone 4 was prepared via the reaction of hydrazonoyl chlorides 2 with 2amino-tetrahydrobenzo[b]thiophene-3-carboxylic acid 1 followed by cyclization with 1,1`-carbonyldiimidazole. Furthermore, benzothienothiadiazolo pyrimidinone derivatives 11a-c were prepared. The structure of the newly synthesized compounds were established on the basis of spectral data...

High Internal Phase Emulsion hydrogels are prepared from waterborne poly(N-isopropylacrylamide) nanogel dispersions which are non-covalently crosslinked through 2-ureido-4[1H] pyrimidinone (UPy) quadruple hydrogen bond groups. The reversible UPy crosslinks allow for the HIPE-hydrogels to be molded into objects which are thermo-responsive in nature.

The asymmetric unit of the title compound, C(12)H(14)N(2)O(4), contains two independent mol-ecules. In one independent mol-ecule, the furanyl fragment is rotationally disordered between two orientations in a 0.625 (6):0.375 (6) ratio. In the crystal, inter-molecular pyrimidine-pyrimidinone N-H⋯O hydrogen bonds link the mol-ecules into centrosymmetric tetra-mers, which are further associated int...

The syntheses of various pyrimidinones as potentially bioactive products by means of the highly controlled continuous-flow retro-Diels-Alder reaction of condensed pyrimidinone derivatives are presented. Noteworthy, the use of this approach allowed us to rapidly screen a selection of conditions and quickly confirm the viability of preparing the desired pyrimidinones in short reaction times. Yiel...

Chemotherapy represents the most applied approach to cancer treatment. Owing frequent onset of chemoresistance and tumor relapses, there is an urgent need discover novel more effective anticancer drugs. In search for therapeutic alternatives treat disease, a series hybrid pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered with hydrazide-hydrazones, 5a–h, was synthesized from condensation reaction pyr...