Spherically agglomerated solid dispersions of carvedilol (CAR) were prepared with polyvinyl-pyrrolidone (PVP) using acetone, water and dichloromethane as solvent, non-solvent and bridging liquid, respectively. The prepared agglomerates were evaluated for its percentage yield, drug content, morphology, thermal behavior, micromeritic properties, aqueous solubility and in vitro drug release. Diffe...

Poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. In this study, organic solvent-free solid dispersions (OSF-SDs) containing telmisartan (TEL) were prepared using polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 6000 (PEG 6000) as hydrophilic polymers, sodium hydroxide (NaOH) as an alkalizer, and ...

The oral Bioavailability of BCS (Bio Pharmaceutical Classification System) class II drug with poor solubility and reasonable permeability is limited by drug dissolution. The purpose of this research was to obtain enhancement of the dissolution profile of Mefenamic acid (MA) using solid dispersion technique with hydrophilic polymers such as poly ethylene glycol (PEG), polyvinyl pyrrolidone (PVP)...

Surface expression of the group 1 K30 capsular polysaccharide of Escherichia coli strain E69 (O9a:K30) requires Wza(K30), a member of the outer membrane auxiliary (OMA) protein family. A mutation in wza(K30) severely restricts the formation of the K30 capsular structure on the cell surface, but does not interfere with the biosynthesis or polymerization of the K30 repeat unit. Here we show that ...

Pharmacognosy Research,2023,15,1,64-70.DOI:10.5530/097484900244Published:December 2022Type:Original ArticleAuthors:Poojashree Verma, Neelesh Maheshwari, and Deepika Bairagee Author(s) affiliations:Poojashree Verma1, Maheshwari2, Bairagee1,* 1Faculty of Pharmacy, PAHER University, Udaipur, Rajasthan, INDIA. 2School Sangam Bhilwara, Abstract:Aim: The present research aimed to formulate a transder...

objective (s): mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.materials and methods:everydiscs containing 70 mg stem bark extract of ziziphus jujuba were formulated  by using carbopol 934, pvp k30 and gelatin as polymers. discs were made by granulation  and direct compression. discs were standardized based on the total phenol.  properties such as in vi...

OBJECTIVE S Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease. MATERIALS AND METHODS Every discs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitr...

Objective: The objective of the present investigation was to improve dissolution characteristics of EZE, which might offer improved bioavailability. Method: The solid dispersion of Ezetimibe was prepared by Solvent evaporation method by using 1:1, 1:2 and 1:3 ratios of drug and polymers (PVP K-30, Sodium starch glycolate). The tablets were prepared by direct compression method. The compressed t...

Objective: Methotrexate (MTX) is a folate antimetabolite used for the management of neoplastic diseases like leukemia and breast cancer, also in treatment psoriasis as well rheumatoid arthritis. The goal this research was to improving solubility dissolution profile methotrexate solid dispersion by using different polymers. Methods: A total six formulas were prepared solvent evaporation method p...