The effects of caudal cannulation on the blood physiology of the Port Jackson shark, Heterodontus portusjacksoni, were investigated in sharks given between 4 and 72 h to recover from surgery. Neither the PaO2–PvO2 difference nor the CaO2–CvO2 difference of cannulated sharks fluctuated throughout the sampling period. The plasma acidosis exhibited 4 h after surgery was partially compensated after...

The aim of the study was to assess the impact of the intrinsic positive end-expiratory pressure (PEEPi) on pulmonary gas exchange in mechanically-ventilated patients, by comparing the effects of similar levels (0.8-0.9 kPa) of positive end-expiratory pressure (PEEP) and PEEPi. Ten patients with acute respiratory failure, without chronic airway disease, were studied with three ventilatory modes:...

AIMS To evaluate the prognostic significance of traditional cardiopulmonary exercise testing (CPET) parameters in chronic heart failure (CHF) patients treated with beta-blockers. METHODS AND RESULTS A total of 631 CHF patients were followed for cardiovascular death over 3.8 +/- 1.4 years; among them 79 (13%) died. All prognostic CPET parameters were related to outcome at univariate analysis, ...

INTRODUCTION A pneumatic tube system (PTS) is a cost-effective, rapid transport modality that utilizes induced pressure changes. We evaluated the clinical importance of 2 transport modalities, human courier and PTS, for blood gas specimens. METHODS Following open heart surgery, 35 simultaneous pairs of arterial and venous blood gas specimens were analyzed from 20 subjects. Of each pair, one s...

Hypertrophic cardiomyopathy (HCM) is the most common congenital disease increasing risk of sudden cardiac death. For many years, HCM patients were excluded from exercise training. However, there are data showing that with undergoing supervised training could improve physical performance without serious adverse events. A project was designed as a randomized clinical trial to assess effectiveness...

We aimed to validate the mathematical validity and accuracy of the respiratory components of the Nottingham Physiology Simulator (NPS), a computer simulation of physiological models. Subsequently, we aimed to assess the accuracy of the NPS in predicting the effects of a change in mechanical ventilation on patient arterial blood-gas tensions. The NPS was supplied with the following measured or c...

BACKGROUND Resection is the treatment of choice for lung cancer, but may cause impaired cardiopulmonary function with an adverse effect on quality of life. Few studies have considered the effects of thoracotomy alone on lung function, and whether the operation itself can impair subsequent exercise capacity. METHODS Patients being considered for lung resection (n = 106) underwent full static a...

INTRODUCTION The administration of crystalloid fluids is considered as the first line treatment in management of trauma patients. Infusion of intravenous fluids leads to various changes in hemodynamic, metabolic and coagulation profiles of these patients. The present study attempted to survey some of these changes in patients with mild severity trauma following normal saline infusion. METHODS...

OBJECTIVES Although fluid resuscitation guided by central venous oxygen saturation (SvcO2) is currently considered the gold standard in sepsis therapy, few studies have described hemodynamic and perfusion parameters during this procedure. This study aims to describe these parameters during septic shock without resuscitation and after 12 hours of goal-directed resuscitation. METHODS Thirteen a...

OBJECTIVE This study aimed to show the changes in oxidative stress and clinical condition from either chest physical therapy (CPT) or CPT with aerosol treatment in infant patients with pneumonia. METHODS From 52 intubated patients, three groups were composed: groups A, B, and C comprising 21 patients aged 5.3±0.6 months (CPT program), 20 patients aged 5.6±0.7 months (aerosol treatment before ...