نتایج جستجو برای: purinoceptor
تعداد نتایج: 1979 فیلتر نتایج به سال:
The majority of studies of the functional distribution of purinoceptors have been carried out with mammalian preparations. The objective of this article is to review the disparate literature describing purinoceptor-mediated effects in invertebrates and lower vertebrates and, in view of the concept that ontogeny repeats phylogeny, to review also the evidence for purinoceptor involvement in the c...
BACKGROUND Hepatic stellate cells (HSC) are important mediators of liver fibrosis. HSC express purinergic receptors for extracellular ATP that induce fibrogenesis. Pyridoxal-phosphate-6-azophenyl-2', 4'-disulfonate (PPADS) is a highly bioavailable purinoceptor inhibitor. We sought to determine whether PPADS could prevent experimental liver fibrosis in rats. MATERIALS AND METHODS The effect of...
It has recently been reported that bradykinin induces selective left ventricular (LV) relaxation in isolated guinea pig hearts via the release of nitric oxide. Exogenous bradykinin also induces vasodilation, which is only partly due to nitric oxide release. In the present study we investigated the role of adenyl purines on these bradykinin-induced effects. Isolated ejecting guinea pig hearts we...
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