In this paper, we propose a dynamical model for pulsatile flow estimation of an iRBP. Noninvasive measurements of the motor power (V I) and pump impeller rotational speed (ω) were acquired from the pump controller and used together with blood hematocrit (HCT ) values as inputs to the model. A circulatory mock loop was operated with different aqueous glycerol solutions, mimicking different value...

A preliminary comparative measurement between particle imaging velocimetry (PIV) and laser speckle contrast analysis (LASCA) to study pulsatile flow using ventricular assist device in a patient-specific carotid artery phantom is reported. These full-field optical techniques have both been used to study flow and extract complementary parameters. We use the high spatial resolution of PIV to gener...

This study numerically investigates turbulent pipe flow driven by a pulsating pressure gradient. While studies of laminar and turbulent pulsatile pipe flow with a single mode of oscillating pressure gradient have been carried out extensively, there is scarce literature on pulsating pressure gradients with multiple temporal Fourier modes. In many real-life engineering applications, for example, ...

Synchrotron X-ray imaging technique has been used to investigate biofluid flows in a non-destructive manner. This study aims to investigate the feasibility of the X-ray PIV technique with CO2 microbubbles as flow tracer for measurement of pulsatile blood flows under in vivo conditions. The traceability of CO2 microbubbles in a pulsatile flow was demonstrated through in vitro experiment. A rat e...

The effects of pulsatile and non-pulsatile cardiopulmonary bypass (CPB) on levels of peripheral vascular resistance and plasma angiotensin II (AII) have been studied in 24 patients submitted to elective cardiac surgical procedures. Twelve patients had conventional non-pulsatile perfusion throughout the period of CPB (non-pulsatile group), while 12 had pulsatile perfusion during the central peri...

Drug-eluting stents reside in a dynamic fluid environment where the extent to which drugs are distributed within the arterial wall is critically modulated by the blood flowing through the arterial lumen. Yet several factors associated with the pulsatile nature of blood flow and their impact on arterial drug deposition have not been fully investigated. We employed an integrated framework compris...

Liver neo-tissue suitable for transplantation has not been established. Primary rat hepatocytes were cultured on three-dimensional biodegradable polymer matrices in a pulsatile flow bioreactor with the intention of inducing tissue formation and improving cell survival. Functional and structural analysis of the hepatocytes forming liver neo-tissue was performed. Biodegradable poly(L-lactic acid)...

Huo, Yunlong, and Ghassan S. Kassab. Pulsatile blood flow in the entire coronary arterial tree: theory and experiment. Am J Physiol Heart Circ Physiol 291: H1074–H1087, 2006. First published April 14, 2006; doi:10.1152/ajpheart.00200.2006.—The pulsatility of coronary circulation can be accurately simulated on the basis of the measured branching pattern, vascular geometry, and material propertie...