Benzo[j]fluoranthene (B[j]F), trans-4,5-dihydro-4,5-dihydroxy-B[j]F, and trans-9,10-dihydro-9,10-dihydroxy-B[j]F were evaluated for tumorigenic activity in newborn CD1 mice. These dihydrodiols were assayed at doses of 1.10 and 0.275 mumol/mouse. B[j]F and the syn- and anti-diol epoxides derived from these dihydrodiols were evaluated at doses of 1.10, 0.275, and 0.110 mumol/mouse (80 mice/group)...

PURPOSE This study aimed to investigate the expression of the ErbB family of receptor tyrosine kinases in pulmonary typical carcinoid and atypical carcinoid tumors and to understand the role of epidermal growth factor receptor (EGFR) signaling in pulmonary carcinoid tumor proliferation. EXPERIMENTAL DESIGN Surgically resected typical carcinoid (n = 24) and atypical carcinoid (n = 7) tumor tis...

background: neuroectodermal tumors (pnet) are malignant small cells neoplasm mainly occurring in children but can occur at any age. extensive bleeding into the pleural cavity is rare in children. hemothorax would be compatible with a variety of congenital anomalies including sequestration, patent ductus artreiosus, and pulmonary arteriovenous malformation. case report: a 2.5-years old girl who ...

Primary hepatocellular carcinoma (HCC) is the third leading causes of cancer-related death worldwide and its five-year survival rate is under 10% [1,2]. The lungs are most common sites of metastasis of HCC and pulmonary metastatic rate of HCC is estimated around 45% [3]. After comprehensive treatment of HCC, the patients’ survival time is prolonged but companied with a high rate of late pulmona...

BACKGROUND Few studies on how to diagnose pulmonary neuroendocrine tumors through morphometric analysis have been reported. In this study, we measured and analyzed the characteristic parameters of pulmonary neuroendocrine tumors using an image analyzer to aid in diagnosis. METHODS Sixteen cases of typical carcinoid tumor, 5 cases of atypical carcinoid tumor, 15 cases of small cell carcinoma, ...

BACKGROUND Recent studies indicate that Transforming Growth Factor beta (TGF β) correlated with pulmonary metastasis of cancers. However, the correlation between TGF β and pulmonary metastasis of hepatocellular carcinoma (HCC) is till unknown. METHODS We detected the in vitro and in vivo expression levels of TGF β1/Smads by Real-time PCR and Western blot in MHCC97-H and MHCC97-L cell lines, w...