Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the β-subunit KCNE1 form the cardiac IKs channel that is central for cardiac repolarization. In this study, we explore the prospects of PUFAs as IKs channel modulators. We report that PUFAs open Kv7.1 via an electrostatic mechanism. Both the polyunsaturated acyl tail and the negatively charged carboxyl head group are req...

Introduction: Dental caries is still a major health problem in most countries as it school-aged children and adults also. continues to be public problem, especially low- middle- income countries. It can prevented treated with proper utilization of dental services. Untreated have pain infection significant impact on general health. Method: This study was conducted assess the untreated using pufa...

High saturated fatty acid (SFA) diets contribute to the development of insulin resistance, whereas fish oil-derived n-3 polyunsaturated fatty acids (PUFA) increase the secretion of adiponectin (Ad), an adipocyte-derived protein that stimulates fatty acid oxidation (FAO) and improves skeletal muscle insulin response. We sought to determine whether fish oil could prevent and/or restore high SFA d...

Sir, We have read with interest the paper concerning the antiproteinuric effect of polyunsaturated fatty acid (PUFA) in IgA patients [1]. The authors mentioned that the evaluation of effectiveness of PUFA in IgA therapy gave conflicting results. Their results suggested that the hypoalbuminuric effect of PUFA was detected in the patients on ACEi/ARB therapy in which a haemodynamic-dependent fact...

Fish oil, enriched in bioactive n-3 polyunsaturated fatty acids (PUFA), has been shown to play a role in prevention of colon cancer. The effects of n-3 PUFA are pleiotropic and multifaceted, resulting in an incomplete understanding of their molecular mechanisms of action. Here, we focus on a highly conserved mechanism of n-3 PUFA, which is the alteration of the organization of the plasma membra...

BACKGROUND The effects of omega-3 polyunsaturated fatty acids (PUFA) on the prevention of postoperative atrial fibrillation (POAF) are inconclusive in current studies. Moreover, the most appropriate composition of PUFA to play the protective role is unclear. The aim of this meta-analysis was to ascertain the protective role of PUFA on POAF and the most appropriate composition. METHODS Studies...

Polyunsaturated fatty acid (PUFA) status has been associated with neuropsychiatric disorders, including depression and risk of suicide. Long-chain PUFAs (LC-PUFAs) are obtained in the diet or produced by sequential desaturation and elongation of shorter-chain precursor fatty acids linoleic acid (LA, 18:2n-6) and α-linolenic acid (ALA, 18:3n-3). We compared DNA methylation patterns in genes invo...

Phytochemical plant tannins are phenolic compounds that interfere with biohydrogenation (BH) of monounsaturated-(MUFA) and poly-unsaturated fatty acids (PUFA). The objective of the present animal study was to investigate the effects of three different levels of phytochemical tannin-containing ground pine bark diet on fatty acid profiles of goat meat, with particular reference to MUFA and PUFA. ...

Polyunsaturated fatty acids (PUFAs) are critical to nervous system function and structure, but their rates of incorporation from plasma into brain have not been evaluated. In the adult rat, calculations based on our model show that at least 3;-5% of esterified brain arachidonic acid (AA) and 2;-8% of esterified brain docosahexaenoic acid (DHA) are replaced daily by unesterified PUFAs in plasma....