BACKGROUND One of the most important thyroid hormone targets is the cardiovascular system. Hemodynamic changes, such as decreased resting heart rate (HR), myocardial contractility, and cardiac output, and increased diastolic pressure and systemic vascular resistance, have been observed in hypothyroid patients. Moreover, in these patients, ECG changes include sinus bradycardia and low voltage co...

INTRODUCTION Recent advances suggest that the cellular redox state may play a significant role in the progression of fibrosis in systemic sclerosis (SSc). Another, and as yet poorly accounted for, feature of SSc is its overlap with thyroid abnormalities. Previous reports demonstrate that hypothyroidism reduces oxidant stress. The aim of this study was therefore to evaluate the effect of propylt...

Propylthiouracil (PTU) inhibits peripheral deiodination of thyroxine (T4) and triiodothyronine (T3) and decreases the metabolic effectiveness of T4 in animals. To assess the effect of PTU on extrathyroidal conversion of T4 to T3 in man, 15 studies were performed in athyreotic patients treated with 100 or 200 mug of L-T4 daily for 1 mo before the addition of PTU, 250 mg every 6 h for 8 days. se...

The present study proposes to measure the thermal requirements, heat and radiation use efficiency of kharif soybean cultivars (NRC 37, GS 1 2) in central region Gujarat. findings conclude that among all different geometry 30 x 10 cm produced highest seed (4403 kg/ha) total biomass yield (5818 over other two spacing because higher (heat (HUE) for Growing degree day (GDD)- 0.69 kg/ha/°C Day; HUE ...

Astrac t l . Forty-eight chicks (21 days old) were implanted (+ 50 mg 17-fl estradiol; EBI) and fed diets containing + 0.1% propylthiouracil (PTU) for 7 days to determine the role of gonadal hormones in the regulation of energy metabolism in the hypothyroid chick. 2. In vitro lipogenesis (IVL) and glucose production (NGP) were measured in liver explants. 3. Liver glycogen (GLY) metabolism was s...

Reduced thyroid hormone concentrations (T4 and/or T3) and increased thyroid-stimulating hormone (TSH) have been proposed to mediate the thyroid tumor promoting effects of hepatic microsomal enzyme inducers (MEI) and antithyroid drugs. TSH is known to stimulate thyroid gland function and growth, as well as neoplasia. Thyroid weight has been used as an indicator of thyroid gland growth in MEI stu...

were given 0-1% propylthiouracil (PTU) in drinking water, and their offspring were examined. They were found to be practically deaf, and to have serious abnormalities in the inner ear. Addition of thyroxine to the drinking water containing PTU resulted in normal hearing and a normal inner ear, showing that the abnormalities were not caused by PTU as such, but were the consequence ofits inhibito...

Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the clinical presentation, histological characteristics, and posttransplant managem...

INTRODUCTION The purpose of this study was to determine whether final-year undergraduate dental students achieved better shaping outcomes using the new ProTaper Next (PTN; Dentsply Sirona, Ballaigues, Switzerland) system to prepare root canals for the first time compared with the existing ProTaper Universal (PTU, Dentsply Sirona) system on which they had trained. A secondary aim was to explore ...

Experiments were conducted to address recent reports of precocial testis development or testicular hypertrophy induced by the anti-thyroid agent 6-N-propyl-2-thiouracil (PTU) in domestic fowl and rodents. In three experiments, PTU was administered to male turkeys during different stages of development. The PTU was given in the feed at a concentration of either 0.1 or 0.5% and effects on thyroid...